Functional Brain Science Laboratory, Center for Development of Advanced Medical Technology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Brain Lang. 2012 Jun;121(3):185-93. doi: 10.1016/j.bandl.2012.02.001. Epub 2012 Mar 17.
Confrontation naming tasks assess cognitive processes involved in the main stage of word production. However, in fMRI, the occurrence of movement artifacts necessitates the use of covert paradigms, which has limited clinical applications. Thus, we explored the feasibility of adopting multichannel functional near-infrared spectroscopy (fNIRS) to assess language function during covert and overt naming tasks. Thirty right-handed, healthy adult volunteers underwent both naming tasks and cortical hemodynamics measurement using fNIRS. The overt naming task recruited the classical left-hemisphere language areas (left inferior frontal, superior and middle temporal, precentral, and postcentral gyri) exemplified by an increase in the oxy-Hb signal. Activations were bilateral in the middle and superior temporal gyri. However, the covert naming task recruited activation only in the left-middle temporal gyrus. The activation patterns reflected a major part of the functional network for overt word production, suggesting the clinical importance of fNIRS in the diagnosis of aphasic patients.
命名任务评估了单词生成主要阶段涉及的认知过程。然而，在 fMRI 中，运动伪影的发生需要使用隐蔽范式，这限制了其临床应用。因此，我们探索了采用多通道功能近红外光谱 (fNIRS) 评估隐蔽和显性命名任务期间语言功能的可行性。30 名右利手健康成年志愿者接受了命名任务和 fNIRS 测量的皮质血液动力学。显性命名任务招募了经典的左半球语言区域（左额下回、上颞叶和中颞叶、中央前回和中央后回），以氧合血红蛋白信号增加为特征。激活在中颞叶和上颞叶是双侧的。然而，隐蔽命名任务仅在左中颞叶招募激活。激活模式反映了显性单词生成的功能网络的主要部分，表明 fNIRS 在失语症患者诊断中的临床重要性。
