Inamoto Kyoko, Sakuma Shigemitsu, Ariji Yoshiko, Higuchi Naoya, Izumi Masahiro, Nakata Kazuhiko
Department of Endodontics, School of Dentistry, Aichi Gakuin University, Aichi, Japan.
Department of Fixed Prosthodontics, School of Dentistry, Aichi Gakuin University, Aichi, Japan.
Neurosci Lett. 2015 Feb 19;588:67-71. doi: 10.1016/j.neulet.2014.12.034. Epub 2014 Dec 27.
The aim of this study was to examine cerebral blood volume dynamics during volitional swallowing using multi-channel functional near-infrared spectroscopy (fNIRS) to understand the basic cortical activation patterns. Fifteen volunteers (age, 26.5±1.3 years, mean±SD) performed volitional swallowing of a 5-ml bolus of water as a task. A 52-channel fNIRS system was used for measuring oxy-Hb levels. We determined the oxy-Hb concentration changes in each channel by calculating the differences between rest and task oxy-Hb levels. Differences in rest and task data were assessed using a paired-t test (p<0.05). A significant increase in oxy-Hb was found in 21 channels. The cortical regions that exhibited increased oxy-Hb concentration included the bilateral precentral gyrus, postcentral gyrus, inferior frontal gyrus, superior temporal gyrus, middle temporal gyrus, and supramarginal gyrus. These data provide a description of cortical activation patterns during volitional swallowing using fNIRS, which will be useful for the evaluation of dysphasia and the effects of the rehabilitation [Corrected].
本研究的目的是使用多通道功能近红外光谱技术（fNIRS）检测自主吞咽过程中的脑血容量动态变化，以了解基本的皮层激活模式。15名志愿者（年龄26.5±1.3岁，均值±标准差）将5毫升水作为任务进行自主吞咽。使用52通道fNIRS系统测量氧合血红蛋白（oxy-Hb）水平。通过计算静息和任务状态下oxy-Hb水平的差异，确定每个通道中oxy-Hb浓度的变化。使用配对t检验评估静息和任务数据的差异（p<0.05）。在21个通道中发现oxy-Hb显著增加。显示oxy-Hb浓度增加的皮层区域包括双侧中央前回、中央后回、额下回、颞上回、颞中回和缘上回。这些数据描述了使用fNIRS进行自主吞咽时的皮层激活模式，这将有助于吞咽困难的评估和康复效果[已修正]。
