克林霉素、亚胺培南、甲硝唑和哌拉西林-他唑巴坦对脆弱拟杆菌敏感和耐药分离株的体外活性评价——通过杀菌动力学。
In vitro activities of clindamycin, imipenem, metronidazole, and piperacillin-tazobactam against susceptible and resistant isolates of Bacteroides fragilis evaluated by kill kinetics.
机构信息
Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany. reiner.schaumann@medizin
出版信息
Antimicrob Agents Chemother. 2012 Jun;56(6):3413-6. doi: 10.1128/AAC.00099-12. Epub 2012 Mar 19.
Abstract
The aim of the present study was to investigate the activities of clindamycin, imipenem, metronidazole, and piperacillin-tazobactam against 12 Bacteroides fragilis isolates (resistant and susceptible strains) by kill kinetics over 24 h. In contrast to the other antimicrobial agents, clindamycin did not affect strains with MICs of >8.0 μg/ml. For those strains with MICs of ≤ 8.0 μg/ml, all employed antibiotics except clindamycin showed nearly bactericidal activity. Metronidazole proved to be the most active antimicrobial agent.
摘要
本研究旨在通过 24 小时的杀菌动力学实验，检测克林霉素、亚胺培南、甲硝唑和哌拉西林-他唑巴坦对 12 株脆弱拟杆菌（耐药株和敏感株）的活性。与其他抗菌药物不同，克林霉素对 MIC 值>8.0 μg/ml 的菌株没有影响。对于 MIC 值≤8.0 μg/ml 的菌株，除克林霉素外，所有使用的抗生素均显示出近乎杀菌的活性。甲硝唑是最有效的抗菌药物。
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