Falagas M E, McDermott L, Snydman D R
Department of Pathology (Clinical Microbiology), New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Antimicrob Agents Chemother. 1997 Sep;41(9):2047-9. doi: 10.1128/AAC.41.9.2047.
We studied the effect of pH (7.1, 6.3, and 5.8) on the in vitro susceptibilities of 59 isolates of Bacteroides fragilis and 60 isolates of other B. fragilis group species to trovafloxacin, ciprofloxacin, clindamycin, ampicillin-sulbactam, piperacillin-tazobactam, imipenem, and meropenem. For each agent tested the geometric mean MIC was highest at pH 5.8, intermediate at pH 6.3, and lowest at pH 7.1. The magnitude of the pH effect varied greatly among different antibiotics. These data show that an acidic pH decreases the in vitro susceptibilities of the B. fragilis group to several antibiotics.
我们研究了pH值（7.1、6.3和5.8）对59株脆弱拟杆菌和60株其他脆弱拟杆菌属菌种的体外药敏性的影响，这些菌种对曲伐沙星、环丙沙星、克林霉素、氨苄西林-舒巴坦、哌拉西林-他唑巴坦、亚胺培南和美罗培南的药敏性。对于每种测试药物，几何平均最低抑菌浓度（MIC）在pH 5.8时最高，在pH 6.3时居中，在pH 7.1时最低。pH值影响的程度在不同抗生素之间差异很大。这些数据表明，酸性pH值会降低脆弱拟杆菌属对几种抗生素的体外药敏性。
