Ingold Ana J, Castro Mercedes, Nabón Adriana, Borthagaray Graciela, Márquez Carolina
Cátedra de Microbiología, Departamento de Bioquímica Clínica, Facultad de Química, Universidad de la República.
Rev Argent Microbiol. 2011 Jul-Sep;43(3):198-202. doi: 10.1590/S0325-75412011000300004.
In order to analyze the presence of metallo-ß-lactamase in our country, we included in this study Pseudomonas aeruginosa isolates causing nosocomial infections in a hospital from Uruguay. The presence of a metallo-ß-lactamase VIM-2 in a class 1 integron and of an extended spectrum -lactamase CTX-M-2 was detected in one isolate. This is the first report of both genes, bla(CTX-M-2) and bla(VIM-2),in the same P. aeruginosa isolate. Although carbapenemases have been extensively documented in the world, this is the first report of an acquired metallo-ß-lactamase with carbapenemase activity in pathogenic bacteria in Uruguay.
为了分析我国金属β-内酰胺酶的存在情况，我们将乌拉圭一家医院中引起医院感染的铜绿假单胞菌分离株纳入本研究。在一株分离株中检测到1类整合子中存在金属β-内酰胺酶VIM-2以及超广谱β-内酰胺酶CTX-M-2。这是bla(CTX-M-2)和bla(VIM-2)这两个基因在同一铜绿假单胞菌分离株中的首次报道。尽管碳青霉烯酶在全球已有广泛记录，但这是乌拉圭病原菌中获得性具有碳青霉烯酶活性的金属β-内酰胺酶的首次报道。
