Washington University, Department of Obstetrics and Gynecology, St. Louis, MO, USA.
Obstet Gynecol. 2012 Apr;119(4):732-6. doi: 10.1097/AOG.0b013e31824c096c.
To compare first-stage labor patterns in women undergoing trial of labor after cesarean delivery (TOLAC) and those without a previous cesarean to explore whether a uterine scar alters this stage of labor.
A retrospective cohort study was conducted of consecutive term vertex singletons who reached the second stage of labor. Cervical examinations and obstetric outcomes were collected from medical records. Labor curves of those laboring spontaneously, stratified by TOLAC status, were constructed using a repeated-measures analysis. Interval-censored regression was used to estimate duration of labor, centimeter by centimeter, stratified by TOLAC status and adjusted for race, obesity, macrosomia, and previous vaginal delivery.
Of 5,388 consecutive term births, 2,021 labored spontaneously and were included. The 1,881 laboring women with no previous cesarean delivery were compared with 140 women undergoing TOLAC. There was no significant difference in rates of cervical dilation between the groups. The median time for dilation from 4 to 10 cm was 3.0 hours for TOLAC and 2.8 hours for non-TOLAC (P=.52). A post hoc sample size calculation (alpha=0.05) shows 90% power to detect a median difference of 0.4 hours with the fixed sample size available.
There was no significant difference in first-stage labor curves or cervical dilation rate between women undergoing TOLAC and those without a previous cesarean. Diagnoses of labor disorders should be made with similar standards between those with and without a uterine scar.
II.
比较剖宫产后试产(TOLAC)和无既往剖宫产史的产妇第一产程模式,探讨子宫瘢痕是否改变该产程。
对连续的足月头位单胎孕妇进行回顾性队列研究,这些孕妇已进入第二产程。从病历中收集宫颈检查和产科结局。使用重复测量分析为自然分娩的孕妇构建产程曲线,根据 TOLAC 状态分层。采用区间 censored 回归估计 TOLAC 状态和调整种族、肥胖、巨大儿和既往阴道分娩分层后的每厘米产程持续时间。
在 5388 例连续足月分娩中,有 2021 例自发分娩,纳入研究。将 1881 例无既往剖宫产分娩的孕妇与 140 例 TOLAC 孕妇进行比较。两组宫颈扩张率无显著差异。从 4cm 扩张至 10cm 的中位时间为 TOLAC 组 3.0 小时,非 TOLAC 组 2.8 小时(P=.52)。事后样本量计算(alpha=0.05)显示,在可用的固定样本量下,有 90%的效能可检测到 0.4 小时的中位数差异。
TOLAC 孕妇与无既往剖宫产孕妇的第一产程曲线或宫颈扩张率无显著差异。对于有和无子宫瘢痕的孕妇,应采用相同的标准来诊断产程障碍。
II。