Epidemiology Branch and the Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, and the Pregnancy and Perinatology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland; the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, Pennsylvania; and the Division of Education & Research Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, Delaware.
Obstet Gynecol. 2018 Feb;131(2):345-353. doi: 10.1097/AOG.0000000000002431.
To assess the morbidity associated with continuing the second-stage duration of labor, weighing the probability of spontaneous vaginal birth without morbidity compared with birth with serious maternal or neonatal complications.
In a retrospective cohort, we analyzed singleton, vertex births at 36 weeks of gestation or greater without prior cesarean delivery (n=43,810 nulliparous and 59,605 multiparous women). We calculated rates of spontaneous vaginal birth and composite serious maternal or neonatal complications. Results were stratified by parity (nulliparous or multiparous) and epidural status (yes or no). Competing risks models were created for 1) spontaneous vaginal birth with no morbidity, 2) birth with maternal or neonatal morbidity, and 3) no spontaneous vaginal birth and no morbidity, and our main interest was in comparing number 1 against number 2.
Rates of spontaneous vaginal birth without morbidity were slightly higher after the first half hour (greater than 0.5-1.0 hours) for nulliparous women, after which rates decreased with increasing second-stage duration. For multiparous women, rates of spontaneous vaginal birth without morbidity decreased with increasing second-stage duration. For illustration, for a nulliparous woman with an epidural at 3.0 hours of the second stage of labor who extended by another 1.0 hour, her likelihood of delivering by spontaneous vaginal birth was 31.4% compared with her likelihood of birth with any serious complication in the subsequent hour, which was 7.6%. The percentage of cesarean deliveries for nonreassuring fetal heart rate tracing were higher for women without compared with women with an epidural.
Rates of spontaneous vaginal birth without serious morbidity steadily decreased for increasing second-stage duration except for the first half hour for nulliparous women. We did not observe an inflection point at a particular hour mark for either spontaneous vaginal delivery without morbidity or births with morbidity. Our findings will assist in decision-making for extending second-stage duration.
评估继续第二产程持续时间相关的发病率,权衡无并发症的自然阴道分娩的可能性与伴有严重母亲或新生儿并发症的分娩的可能性。
在回顾性队列中,我们分析了无先前剖宫产分娩史的 36 周及以上的单胎头位分娩(43810 例初产妇和 59605 例经产妇)。我们计算了自然阴道分娩率和复合严重母亲或新生儿并发症率。结果按产次(初产妇或经产妇)和硬膜外麻醉状态(是或否)分层。为 1)无并发症的自然阴道分娩,2)伴有母亲或新生儿并发症的分娩,3)无自然阴道分娩且无并发症,创建了竞争风险模型,我们主要关注的是比较 1)和 2)。
对于初产妇,在第二产程的前半小时(大于 0.5-1.0 小时)后,无并发症的自然阴道分娩率略高,之后随着第二产程的延长,分娩率下降。对于经产妇,无并发症的自然阴道分娩率随着第二产程的延长而下降。例如,对于第二产程 3.0 小时时有硬膜外麻醉且延长 1.0 小时的初产妇,她在随后 1 小时内自然阴道分娩的可能性为 31.4%,而在随后 1 小时内发生任何严重并发症的可能性为 7.6%。无硬膜外麻醉的产妇胎心监护不令人满意的剖宫产率较高。
除了初产妇的前半小时外,随着第二产程持续时间的增加,无严重并发症的自然阴道分娩率稳步下降。我们没有观察到无并发症的自然阴道分娩或有并发症的分娩在特定小时标记处出现拐点。我们的研究结果将有助于决策延长第二产程的持续时间。