桑白皮中具有抗炎和细胞毒性的 2-芳基苯并呋喃。
Anti-inflammatory and cytotoxic 2-arylbenzofurans from Morus wittiorum.
机构信息
Department of Medicinal Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, PR China.
出版信息
Fitoterapia. 2012 Jun;83(4):750-3. doi: 10.1016/j.fitote.2012.03.001. Epub 2012 Mar 10.
Three new 2-arylbenzofurans named wittifuran H, wittifuran I and wittifuran U (1-3) were obtained during our ongoing investigation of an ethanol extract from the stem bark of Morus wittiorum. Their structures were elucidated on the basis of spectroscopic data. Compound 2 displayed potent anti-inflammatory activity and selective cytotoxicity against human gastric cancer cell line BGC-823 with an IC(50) value of 1.45μM.
在对构树茎皮的乙醇提取物进行的持续研究中，我们获得了三种新的 2-芳基苯并呋喃，分别命名为 Wittifuran H、Wittifuran I 和 Wittifuran U（1-3）。根据光谱数据阐明了它们的结构。化合物 2 表现出很强的抗炎活性和对人胃癌细胞系 BGC-823 的选择性细胞毒性，IC50 值为 1.45μM。
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