桑中 2-芳基苯并呋喃衍生物。

2-Arylbenzofuran Derivatives from Morus cathayana.

机构信息

The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, People's Republic of China.

出版信息

J Nat Prod. 2009 May 22;72(5):966-8. doi: 10.1021/np800789y.

DOI:10.1021/np800789y

PMID:19338315

Abstract

Four new 2-arylbenzofuran derivatives, cathafurans A (1), B (2), C (3), and D (4), were isolated from the stem bark of Morus cathayana. Their structures were determined by spectroscopic methods. Compounds 2 and 3 exhibited moderate activities against five human cancer cell lines, with IC(50) values ranging from 6.17 to 9.60 microg/mL.

摘要

从桑科植物构树的茎皮中分离得到了 4 个新的 2-芳基苯并呋喃衍生物，即 cathafurans A（1）、B（2）、C（3）和 D（4）。通过光谱方法确定了它们的结构。化合物 2 和 3 对 5 个人类癌细胞系表现出中等的活性，IC（50）值范围为 6.17 至 9.60 μg/mL。