扭曲血管：症状、病因及生物力学机制
Twisted blood vessels: symptoms, etiology and biomechanical mechanisms.
作者信息
Han Hai-Chao
机构信息
Department of Mechanical Engineering and Biomedical Engineering Program, University of Texas at San Antonio, San Antonio, TX 78249, USA.
出版信息
J Vasc Res. 2012;49(3):185-97. doi: 10.1159/000335123. Epub 2012 Mar 14.
Abstract
Tortuous arteries and veins are commonly observed in humans and animals. While mild tortuosity is asymptomatic, severe tortuosity can lead to ischemic attack in distal organs. Clinical observations have linked tortuous arteries and veins with aging, atherosclerosis, hypertension, genetic defects and diabetes mellitus. However, the mechanisms of their formation and development are poorly understood. This review summarizes the current clinical and biomechanical studies on the initiation, development and treatment of tortuous blood vessels. We submit a new hypothesis that mechanical instability and remodeling could be mechanisms for the initiation and development of these tortuous vessels.
摘要
在人类和动物中，常可观察到动脉和静脉迂曲。虽然轻度迂曲无症状，但严重迂曲可导致远端器官缺血性发作。临床观察已将迂曲的动脉和静脉与衰老、动脉粥样硬化、高血压、基因缺陷和糖尿病联系起来。然而，它们形成和发展的机制仍知之甚少。本综述总结了目前关于迂曲血管起始、发展和治疗的临床和生物力学研究。我们提出一个新的假说，即机械不稳定性和重塑可能是这些迂曲血管起始和发展的机制。
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