Yetkin Ertan, Ileri Mehmet
Yenisehir Hospital, Division of Cardiology, Mersin, Turkey.
Numune Training and Research Hospital, Department of Cardiology, Ankara, Turkey.
Med Hypotheses. 2016 Jun;91:73-76. doi: 10.1016/j.mehy.2016.04.016. Epub 2016 Apr 11.
Venous disease is a common but overlooked clinical problem and is an important mortality and morbidity factor depending on the effected vascular territory. Different contributing factors play role on the clinical manifestation of the disease. Peripheral varices of lower extremities, hemorrhoids, varicoceles, pelvic varicose veins are the vasculopathy of veins running toward heart but against gravity. We hypothesize that all these clinical entities share common pathophysiologic steps in terms of vascular wall remodeling and vessel wall damage. A systematic approaches to both arterial and venous dilating disease in further studies and research would increase our understanding on the pathophysiology of dilating vascular disease and would provoke to find out new treatment modalities. Varicose remodeling of veins occurs by a complex interplay of various factors including both physical forces and extracellular matrix remodeling mechanisms. This article focuses on the systematic aspects of dilating venous disease with a focus on pathophysiology under the term of "Dilating Venous Disease".
静脉疾病是一个常见但被忽视的临床问题，并且根据受影响的血管区域，它是一个重要的死亡率和发病率因素。不同的促成因素在该疾病的临床表现中起作用。下肢外周静脉曲张、痔疮、精索静脉曲张、盆腔静脉曲张是静脉逆重力向心脏流动的血管病变。我们假设，就血管壁重塑和血管壁损伤而言，所有这些临床实体都有共同的病理生理步骤。在进一步的研究中，对动脉和静脉扩张性疾病采取系统的方法将增加我们对扩张性血管疾病病理生理学的理解，并将促使我们找到新的治疗方式。静脉的曲张重塑是由各种因素（包括物理力和细胞外基质重塑机制）的复杂相互作用引起的。本文重点关注扩张性静脉疾病的系统方面，重点是在“扩张性静脉疾病”这一术语下的病理生理学。
