Davis R K, Kelly S M, Parkin J L, Stevens M H, Johnson L P
Department of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City.
Laryngoscope. 1990 Dec;100(12):1306-9. doi: 10.1288/00005537-199012000-00011.
Seventy patients with stage I and II glottic cancer were treated at the University of Utah School of Medicine hospitals from 1980 through 1987. Forty-four patients had stage I cancer and 26 patients had stage II. The overall survival in the stage I group was 82%. Primary site control was 93% with only three deaths due to laryngeal cancer. Local control rates were 93% with CO2 laser excision, 80% with CO2 laser and irradiation, and 67% with radiation alone. Stage II glottic patients had an overall survival of 61.5% with a local control rate of 76%. Twenty-one of 24 patients were treated by full-course irradiation. Of the eight patients who recurred at the primary site, all were irradiation failures who had initial bulky disease and impaired vocal cord mobility. Selective CO2 laser excision was highly effective, whereas radiation therapy results were somewhat disappointing. Open partial laryngectomy should be considered in bulky stage II disease patients.
1980年至1987年期间，犹他大学医学院附属医院对70例I期和II期声门癌患者进行了治疗。其中44例为I期癌症患者，26例为II期患者。I期组的总生存率为82%。原发部位控制率为93%，仅3例死于喉癌。二氧化碳激光切除的局部控制率为93%，二氧化碳激光联合放疗的局部控制率为80%，单纯放疗的局部控制率为67%。II期声门癌患者的总生存率为61.5%，局部控制率为76%。24例患者中有21例接受了全程放疗。在8例原发部位复发的患者中，所有患者均为放疗失败，这些患者最初肿瘤体积较大且声带活动受限。选择性二氧化碳激光切除非常有效，而放射治疗的结果则有些令人失望。对于肿瘤体积较大的II期疾病患者，应考虑行开放性部分喉切除术。
