胃肠道和呼吸道症状与胃食管反流严重程度相关吗？
Do gastrointestinal and respiratory signs and symptoms correlate with the severity of gastroesophageal reflux?
机构信息
Department of Pediatrics, Duzce University School of Medicine, 81620 Konuralp, Duzce, Turkey.
出版信息
BMC Gastroenterol. 2012 Mar 21;12:22. doi: 10.1186/1471-230X-12-22.
BACKGROUND
Gastroesophageal reflux (GER) is a disorder that is common by seen in childhood and may lead to severe complications. In this study, we ascertained the incidence of GER among the children who had typical and atypical complaints of GER and whether there was a difference between two groups comparing the findings of 24-hour pH-meter.
METHODS
39 out of 70 patients with typical and atypical GER symptoms were diagnosed as GER by 24-hour pH-meter monitoring. The patients were divided into three groups, those having gastrointestinal complaints, those having respiratory complaints and those having both gastrointestinal and respiratory symptoms.
RESULTS
Evaluated the GER prevalence in these groups, it was found to be 60% in the gastrointestinal group, 48.6% in the respiratory group and 75% in the mixed group. When pH-meter measurements of GER positive patients were compared within the clinical groups, the fraction of time that pH was lower than 4 was found to be significantly higher in the mixed group (p = 0.004).
CONCLUSIONS
The coexistence of gastrointestinal and respiratory symptoms in the patients with GER may be related to the severe reflux.
背景
胃食管反流（GER）是一种在儿童中常见的疾病，可能导致严重的并发症。在这项研究中，我们确定了有典型和非典型 GER 症状的儿童中 GER 的发病率，以及通过 24 小时 pH 监测比较两组之间的结果，两组之间是否存在差异。
方法
通过 24 小时 pH 监测，对 70 例具有典型和非典型 GER 症状的患者中的 39 例进行 GER 诊断。将患者分为三组，一组有胃肠道症状，一组有呼吸道症状，一组有胃肠道和呼吸道症状。
结果
评估这些组中的 GER 患病率，发现胃肠道组为 60%，呼吸道组为 48.6%，混合组为 75%。当比较 GER 阳性患者的 pH 计测量值在临床组内时，发现混合组 pH 值低于 4 的时间比例显著更高（p = 0.004）。
结论
GER 患者存在胃肠道和呼吸道症状共存可能与严重反流有关。
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