Harvard Medical School, Boston, MA, USA.
Nutr J. 2012 Mar 21;11:17. doi: 10.1186/1475-2891-11-17.
Atrial Fibrillation is highly prevalent in clinical practice affecting approximately 2.3 million people in USA and 4.5 million people in European Union. The aim of the study was to examine the association between nut consumption and incident atrial fibrillation.
Prospective cohort of 21,054 male participants of Physicians' Health Study I. Nut consumption was estimated using food frequency questionnaire and incident atrial fibrillation was ascertained through yearly follow-up questionnaires. Cox regression was used to estimate relative risks of atrial fibrillation.
The average age was 54.6 ± 9.5 years (40.7-87.1). During a mean follow up of 20 years (median 24 years), 3,317 cases of atrial fibrillation occurred. The crude incidence rate was 7.6, 7.4, 8.2, 7.9, and 6.8 cases/1000 person-years for people reporting nut consumption of rarely/never, 1-3/month, 1/per week, 2-6/week, and ≥ 7/week, respectively. Multivariable adjusted hazard ratios (95% CI) for incident atrial fibrillation were 1.00 (ref), 1.00 (0.90-1.11), 1.09 (0.97-1.21), 1.07 (0.95-1.21), and 0.91 (0.70-1.17) for nut consumption from the lowest to the highest category of nut consumption (p for trend 0.26). No statistically significant association between nut consumption and atrial fibrillation was found when stratified by body mass index (BMI < 25 vs ≥ 25 kg/m2) or age (< 65 vs. ≥ 65 years).
Our data did not show an association between nut consumption and incident atrial fibrillation among US male physicians.
心房颤动在临床实践中发病率很高，在美国约有 230 万人，在欧盟约有 450 万人。本研究旨在探讨坚果摄入与心房颤动事件的相关性。
这是一项对 21054 名医师健康研究 I 男性参与者的前瞻性队列研究。使用食物频率问卷估计坚果摄入量，通过每年随访问卷确定心房颤动事件。采用 Cox 回归估计心房颤动的相对风险。
平均年龄为 54.6±9.5 岁（40.7-87.1 岁）。平均随访 20 年（中位随访 24 年）期间，共发生心房颤动 3317 例。报告坚果摄入量很少/从不、1-3 次/月、1 次/周、2-6 次/周和≥7 次/周的人群，心房颤动的粗发病率分别为 7.6、7.4、8.2、7.9 和 6.8 例/1000 人年。多变量校正后的风险比（95%可信区间）为：1.00（参考）、1.00（0.90-1.11）、1.09（0.97-1.21）、1.07（0.95-1.21）和 0.91（0.70-1.17），与坚果摄入量最低到最高组之间的心房颤动风险呈负相关（趋势检验 P=0.26）。在按体质指数（BMI<25 与≥25kg/m2）或年龄（<65 与≥65 岁）分层后，坚果摄入量与心房颤动之间未见统计学显著关联。
我们的数据显示，在美国男性医生中，坚果摄入量与心房颤动事件之间无关联。
