Aizer Anthony, Gaziano J Michael, Cook Nancy R, Manson Joann E, Buring Julie E, Albert Christine M
Center for Arrhythmia Prevention, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Am J Cardiol. 2009 Jun 1;103(11):1572-7. doi: 10.1016/j.amjcard.2009.01.374. Epub 2009 Apr 22.
Limited data suggest that athletes may have a higher risk of developing atrial fibrillation (AF); however, there has been no large prospective assessment of the relation between vigorous exercise and AF. Logistic regression analyses stratified by time were used to assess the association between frequency of vigorous exercise and risk of developing AF in 16,921 apparently healthy men in the Physicians' Health Study. During 12 years of follow-up, 1,661 men reported developing AF. With increasing frequency of vigorous exercise (0, 1, 1 to 2, 3 to 4, 5 to 7 days/week), multivariate relative risks for the full cohort were 1.0 (referent), 0.90, 1.09, 1.04, and 1.20 (p = 0.04). This risk was not significantly increased when exercise habits were updated or in models excluding variables that may be in the biological pathway through which exercise influences AF risk. In subgroup analyses, this increased risk was observed only in men <50 years of age (1.0, 0.94, 1.20, 1.05, 1.74, p <0.01) and joggers (1.0, 0.91, 1.03, 1.30, 1.53, p <0.01), where risks remained increased in all analyses. In conclusion, frequency of vigorous exercise was associated with an increased risk of developing AF in young men and joggers. This risk decreased as the population aged and was offset by known beneficial effects of vigorous exercise on other AF risk factors.
有限的数据表明运动员发生心房颤动（AF）的风险可能更高；然而，对于剧烈运动与AF之间的关系，尚未有大规模的前瞻性评估。在医生健康研究中，采用按时间分层的逻辑回归分析来评估16921名表面健康男性的剧烈运动频率与发生AF风险之间的关联。在12年的随访期间，1661名男性报告发生了AF。随着剧烈运动频率增加（0、1、1至2、3至4、5至7天/周），整个队列的多变量相对风险分别为1.0（参照）、0.90、1.09、1.04和1.20（p = 0.04）。当更新运动习惯时，或者在排除可能处于运动影响AF风险的生物学途径中的变量的模型中，这种风险并未显著增加。在亚组分析中，仅在年龄<50岁的男性（1.0、0.94、1.20、1.05、1.74，p<0.01）和慢跑者（1.0、0.91、1.03、1.30、1.53，p<0.01）中观察到这种风险增加，且在所有分析中风险均持续增加。总之，剧烈运动频率与年轻男性和慢跑者发生AF的风险增加相关。随着人群年龄增长，这种风险降低，并且被剧烈运动对其他AF风险因素的已知有益作用所抵消。
