Department of General and Specialized Surgery "Paride Stefanini", Sapienza University of Rome, 00161 Rome, Italy.
Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Nutrients. 2022 Mar 16;14(6):1260. doi: 10.3390/nu14061260.
Atrial fibrillation (AF) is the most common supraventricular arrhythmia associated with increased cardiovascular and non-cardiovascular morbidity and mortality. As multiple factors may predispose the onset of AF, the prevention of the occurrence, recurrence and complications of this arrhythmia is still challenging. In particular, a high prevalence of cardio-metabolic comorbidities such as the metabolic syndrome (MetS) and in its hepatic manifestation, the non-alcoholic fatty liver disease (NAFLD), have been described in the AF population. A common pathogenetic mechanism linking AF, MetS and NAFLD is represented by oxidative stress. For this reason, in the past decades, numerous studies have investigated the effect of different foods/nutrients with antioxidant properties for the prevention of, and their therapeutic role is still unclear. In this narrative comprehensive review, we will summarize current evidence on (1) the association between AF, MetS and NAFLD (2) the antioxidant role of Mediterranean Diet and its components for the prevention of AF and (3) the effects of Mediterranean Diet on MetS components and NAFLD.
心房颤动（AF）是最常见的与心血管和非心血管发病率和死亡率增加相关的室上性心律失常。由于多种因素可能导致 AF 的发生，因此预防这种心律失常的发生、复发和并发症仍然具有挑战性。特别是，在 AF 人群中已经描述了代谢综合征（MetS）及其肝表现，即非酒精性脂肪性肝病（NAFLD）等心脏代谢合并症的高发率。AF、MetS 和 NAFLD 之间的一个共同发病机制是氧化应激。因此，在过去几十年中，许多研究调查了具有抗氧化特性的不同食物/营养素在预防中的作用，但其治疗作用仍不清楚。在这个叙述性综合综述中，我们将总结关于（1）AF、MetS 和 NAFLD 之间的关联（2）地中海饮食及其成分在预防 AF 中的抗氧化作用，以及（3）地中海饮食对 MetS 成分和 NAFLD 的影响的现有证据。
