AMPK：一种营养和能量传感器，可维持能量平衡。
AMPK: a nutrient and energy sensor that maintains energy homeostasis.
机构信息
Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK.
出版信息
Nat Rev Mol Cell Biol. 2012 Mar 22;13(4):251-62. doi: 10.1038/nrm3311.
Abstract
AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by falling energy status, it promotes ATP production by increasing the activity or expression of proteins involved in catabolism while conserving ATP by switching off biosynthetic pathways. AMPK also regulates metabolic energy balance at the whole-body level. For example, it mediates the effects of agents acting on the hypothalamus that promote feeding and entrains circadian rhythms of metabolism and feeding behaviour. Finally, recent studies reveal that AMPK conserves ATP levels through the regulation of processes other than metabolism, such as the cell cycle and neuronal membrane excitability.
摘要
腺苷酸活化蛋白激酶（AMPK）是一种重要的细胞能量传感器。当能量状态下降时，它会被激活，通过增加参与分解代谢的蛋白质的活性或表达来促进 ATP 的产生，同时通过关闭合成代谢途径来节约 ATP。AMPK 还调节全身水平的代谢能量平衡。例如，它介导作用于下丘脑的促进进食的药物的作用，并使代谢和进食行为的昼夜节律同步。最后，最近的研究表明，AMPK 通过调节除代谢以外的过程来维持 ATP 水平，例如细胞周期和神经元膜兴奋性。
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