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[严重产后出血侵入性治疗后的生育力和妊娠结局]

[Fertility and pregnancy outcome following invasive management of severe postpartum hemorrhage].

作者信息

Capmas P, Picone O, Musset D, Frydman R, Fernandez H

机构信息

Service de gynécologie-obstétrique, hôpital Bicêtre, Assistance publique-Hôpitaux de Paris (AP-HP), 82 rue du Général-Leclerc, Le-Kremlin-Bicêtre, France.

出版信息

J Gynecol Obstet Biol Reprod (Paris). 2012 May;41(3):298-306. doi: 10.1016/j.jgyn.2012.01.001. Epub 2012 Mar 20.

DOI:10.1016/j.jgyn.2012.01.001
PMID:22436862
Abstract

OBJECTIVE

Ligation of the internal iliac arteries and embolization of the uterine arteries are two techniques routinely used in the management of postpartum hemorrhage. The objective of this study was to examine the long-term consequences of these techniques on women's subsequent reproductive outcome and subsequent delivery morbidity.

METHODS

Retrospective study including women who underwent ligation and those who underwent embolization, for the treatment of postpartum hemorrhage. We analyzed resumption of menses, fertility, pregnancy and delivery outcome after each treatment.

RESULTS

The study included 85 women who underwent ligation and 90 who had embolization to treat postpartum hemorrhage. No adverse event related to menses, fertility, or pregnancy outcome followed either treatment. However, the rate of recurrent hemorrhage was high: 26% after ligation and 39% after embolization. All recurrences were treated medically in the ligation group, but in the embolization group, 42% (five of 12 patients) required invasive treatment and 33% (four patients) transfusions.

CONCLUSION

From the perspective of subsequent menses, fertility and pregnancy outcome, both ligation and embolization are safe procedures for the management of postpartum hemorrhage. However, our results showed a high risk of recurrent postpartum hemorrhage after both treatments. Recurrences seemed more serious after the latter.

摘要

目的

髂内动脉结扎术和子宫动脉栓塞术是产后出血管理中常用的两种技术。本研究的目的是探讨这些技术对女性后续生殖结局和分娩并发症的长期影响。

方法

回顾性研究,纳入因产后出血接受结扎术和栓塞术的女性。我们分析了每种治疗后月经恢复情况、生育能力、妊娠及分娩结局。

结果

该研究纳入了85例行结扎术和90例行栓塞术治疗产后出血的女性。两种治疗后均未出现与月经、生育能力或妊娠结局相关的不良事件。然而,复发性出血率较高:结扎术后为26%,栓塞术后为39%。结扎组所有复发性出血均采用药物治疗,但在栓塞组,42%(12例患者中的5例)需要侵入性治疗,33%(4例患者)需要输血。

结论

从后续月经、生育能力和妊娠结局的角度来看,结扎术和栓塞术对于产后出血的管理都是安全的操作。然而,我们的结果显示两种治疗后产后复发性出血的风险都很高。栓塞术后复发性出血似乎更严重。

相似文献

1
[Fertility and pregnancy outcome following invasive management of severe postpartum hemorrhage].[严重产后出血侵入性治疗后的生育力和妊娠结局]
J Gynecol Obstet Biol Reprod (Paris). 2012 May;41(3):298-306. doi: 10.1016/j.jgyn.2012.01.001. Epub 2012 Mar 20.
2
[Ligation of internal iliac arteries for severe hemorrhage in obstetric].[髂内动脉结扎术用于产科严重出血]
Tunis Med. 2012 Mar;90(3):247-51.
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[Intractable postpartum haemorrhages: where is the place of vascular ligations, emergency peripartum hysterectomy or arterial embolization?].[难治性产后出血:血管结扎、急诊围产期子宫切除术或动脉栓塞术的应用地位何在?]
Gynecol Obstet Fertil. 2004 Apr;32(4):320-9. doi: 10.1016/j.gyobfe.2004.02.003.
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Clinical outcome, fertility and uterine artery Doppler scans in women with obstetric bilateral internal iliac artery ligation or embolisation.产科双侧髂内动脉结扎或栓塞女性的临床结局、生育能力及子宫动脉多普勒扫描
J Obstet Gynaecol. 2013 Oct;33(7):701-4. doi: 10.3109/01443615.2013.817976.
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Internal iliac artery ligation for severe postpartum hemorrhage and severe hemorrhage after postpartum hysterectomy.髂内动脉结扎术用于治疗严重产后出血及产后子宫切除术后严重出血。
J Obstet Gynaecol Res. 2010 Jun;36(3):538-43. doi: 10.1111/j.1447-0756.2010.01198.x.
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Serious primary post-partum hemorrhage, arterial embolization and future fertility: a retrospective study of 46 cases.严重原发性产后出血、动脉栓塞与未来生育能力:46例回顾性研究
Hum Reprod. 2008 Jul;23(7):1553-9. doi: 10.1093/humrep/den122. Epub 2008 May 6.
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Impact of pelvic arterial embolization for intractable postpartum hemorrhage on fertility.盆腔动脉栓塞术治疗难治性产后出血对生育能力的影响。
Am J Obstet Gynecol. 2009 Apr;200(4):384.e1-4. doi: 10.1016/j.ajog.2008.11.029. Epub 2009 Feb 14.
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[Internal iliac arteries ligation for intractable obstetrical hemorrhage in Africa].[非洲地区内髂动脉结扎术治疗难治性产科出血]
Gynecol Obstet Fertil. 2009 Jun;37(6):476-80. doi: 10.1016/j.gyobfe.2009.03.026. Epub 2009 May 23.
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Fertility and pregnancy outcomes following uterine devascularization for severe postpartum haemorrhage.
Hum Reprod. 2008 May;23(5):1087-92. doi: 10.1093/humrep/den049. Epub 2008 Mar 5.

引用本文的文献

1
Review of Current Insights and Therapeutic Approaches for the Treatment of Refractory Postpartum Hemorrhage.难治性产后出血治疗的当前见解与治疗方法综述
Int J Womens Health. 2023 Jun 1;15:905-926. doi: 10.2147/IJWH.S366675. eCollection 2023.
2
Gynecological, reproductive and sexual outcomes after uterine artery embolization for post-partum haemorrage.产后出血行子宫动脉栓塞术后的妇科、生殖和性功能结局。
Sci Rep. 2021 Jan 12;11(1):833. doi: 10.1038/s41598-020-80821-0.
3
Short & long term adverse outcomes after arterial embolisation for the treatment of postpartum haemorrhage: a systematic review.
动脉栓塞治疗产后出血的短期和长期不良结局:系统评价。
Eur Radiol. 2017 Feb;27(2):749-762. doi: 10.1007/s00330-016-4395-2. Epub 2016 May 26.