Ruczkowska J, Dolna I, Choroszy-Król I
Z Katedry i Zakładu Mikrobiologii Lekarskiej AM we Wrocławiu.
Przegl Dermatol. 1990 May-Jun;77(3):186-92.
From urethra of 40 men with CTU, 190 bacterial strains were isolated, 110 before and 80 after treatment with OFX (400 mg daily for 5 days). Among the strains coexisting with Chlamydia trachomatis, Staphylococcus epidermidis (30.9%), Micrococcus (13.6%), Streptococcus group D (10.9%) and Staphylococcus aureus (10.9%) were isolated more frequently than others. The in vitro susceptibility testing showed that, in comparison to erythromycin, doxycycline, oxytetracycline and co-trimoxazole, OFX was the most active antimicrobial agent against the majority of bacteria (except streptococci) isolated from urethra in CTU cases in men. The OFX treatment was found to reduce the total number of isolated strains, including Staphylococcus aureus and Staphylococcus saprophyticus, without disturbing normal urethral flora.
从40例患有慢性细菌性尿道炎（CTU）的男性尿道中分离出190株细菌菌株，其中治疗前分离出110株，治疗后（口服氧氟沙星400mg，每日1次，共5天）分离出80株。在与沙眼衣原体共存的菌株中，表皮葡萄球菌（30.9%）、微球菌（13.6%）、D组链球菌（10.9%）和金黄色葡萄球菌（10.9%）的分离频率高于其他菌株。体外药敏试验表明，与红霉素、强力霉素、土霉素和复方新诺明相比，氧氟沙星是对从男性CTU病例尿道中分离出的大多数细菌（链球菌除外）最具活性的抗菌剂。发现氧氟沙星治疗可减少分离菌株的总数，包括金黄色葡萄球菌和腐生葡萄球菌，且不干扰正常尿道菌群。
