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神经精神药理学动物模型再探:向泰特鲍姆致敬

Animal models of neuropsychiatry revisited: a personal tribute to Teitelbaum.

机构信息

Department of Experimental Psychology and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing St., Cambridge, CB2 3EB, UK.

出版信息

Behav Brain Res. 2012 Jun 1;231(2):337-42. doi: 10.1016/j.bbr.2012.03.005. Epub 2012 Mar 14.

Abstract

Several themes and principles of behavioural neuroscience are evident in the work of Phillip Teitelbaum. He has emphasised the importance of studying behaviour in simple preparations, of re-synthesising complex behavioural patterns from these elemental 'building-blocks' and understanding their often hierarchical organisation. He also more recently has become interested in the possible power of behavioural endophenotypes. His work has resulted in a new emphasis on animal neuropsychology which is highly relevant to human psychopathology. This article illustrates these themes from examples taken from animal models of sensory neglect, drug addiction and cognitive syndromes associated with schizophrenia and other neuropsychiatric disorders.

摘要

菲利普·泰特尔鲍姆(Phillip Teitelbaum)的工作中明显体现了行为神经科学的几个主题和原则。他强调了在简单的实验条件下研究行为的重要性,强调了从这些基本“积木”中重新综合复杂行为模式并理解其经常存在的层级组织的重要性。他最近也对行为内表型的潜在作用产生了兴趣。他的工作导致了对动物神经心理学的新关注,这与人类精神病理学密切相关。本文从感觉忽视、药物成瘾和与精神分裂症及其他神经精神障碍相关的认知综合征的动物模型中举例说明了这些主题。

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