Department of Cardiology, Linkoping University Hospital, Linkoping, Sweden.
Age Ageing. 2012 Jul;41(4):468-74. doi: 10.1093/ageing/afs019. Epub 2012 Mar 22.
little is known about demographic and clinical characteristics associated with sleep-disordered breathing (SDB) and obstructive sleep apnoea (OSA) or central sleep apnoea (CSA) in community-dwelling elderly. We also examined these (OSA and CSA) associations to all-cause and cardiovascular (CV) mortality.
a total of 331 community-dwelling elderly aged 71-87 years underwent a clinical examination and one-night polygraphic recordings in their homes. Mortality data were collected after seven years.
a total of 55% had SDB, 38% had OSA and 17% had CSA. Compared with those with no SDB and OSA, more participants with CSA had a left ventricular ejection fraction <50% (LVEF <50%) ischaemic heart disease (IHD) and transient ischaemic attack (TIA)/stroke. There was no difference in the rate of IHD and TIA/stroke between OSA and no SDB, but more LVEF <50% was found in those with OSA. CSA significantly increased the risk for all-cause (P=0.002) and CV mortality (P=0.018) by more than two times. After adjustments for CV disease, diabetes and the biomarker NT-pro-brain natriuretic peptide CSA associations to all-cause mortality and CV mortality lost significance.
OSA, in persons >75 years does not appear to be associated with cardiovascular disease (CVD) disease or mortality, whereas CSA might be a pathological marker of CVD and impaired systolic function associated with higher mortality.
关于社区老年人睡眠呼吸障碍（SDB）和阻塞性睡眠呼吸暂停（OSA）或中枢性睡眠呼吸暂停（CSA）与人口统计学和临床特征的关系，我们知之甚少。我们还检查了这些（OSA 和 CSA）与全因和心血管（CV）死亡率的关系。
共有 331 名 71-87 岁的社区居住老年人在家中接受了临床检查和一夜多导睡眠图记录。在七年后收集死亡率数据。
共有 55%的人患有 SDB，38%的人患有 OSA，17%的人患有 CSA。与没有 SDB 和 OSA 的患者相比，更多患有 CSA 的患者左心室射血分数<50%（LVEF<50%）、缺血性心脏病（IHD）和短暂性脑缺血发作（TIA）/中风。在 OSA 和无 SDB 患者之间，IHD 和 TIA/中风的发生率没有差异，但 OSA 患者的 LVEF<50%更多。CSA 显著增加全因（P=0.002）和 CV 死亡率（P=0.018）的风险超过两倍。在调整了 CV 疾病、糖尿病和生物标志物 NT-pro-脑利钠肽后，CSA 与全因死亡率和 CV 死亡率的关系失去了意义。
在>75 岁的人群中，OSA 似乎与心血管疾病（CVD）或死亡率无关，而 CSA 可能是 CVD 的病理标志物，与更高的死亡率相关的收缩功能障碍。
