Department of Neurology, University of Pécs, 7623 Pécs, Rét u. 2, Hungary.
J Clin Neurosci. 2012 May;19(5):696-701. doi: 10.1016/j.jocn.2011.07.044. Epub 2012 Mar 21.
Migraine and multiple sclerosis (MS) can both cause white matter lesions that appear similar on conventional MRI. This study aimed to compare these abnormalities, and to find anatomical biomarkers specific for migraine. Supratentorial white matter hyperintensities (WMH) of 17 migraineurs and 15 patients with MS were counted, volumetrically analyzed, and their lobar distribution assessed on fluid-attenuated inversion recovery MRI. We found that migraine WMH affected mainly the deep white matter and subcortical U-fibers, belonged to the anterior circulation, appeared more frequently in the frontal and parietal lobes, showed no difference in average size between lobes, and were smaller and fewer than in MS. Most of the MS WMH were in the frontal lobe and were the smallest average size, while the fewest WMH with the largest size were in the occipital lobe. The pattern of supratentorial WMH appearance differs between the two groups; however, accurate differential diagnosis of WMH by conventional MRI is probably not possible in individual patients.
偏头痛和多发性硬化症（MS）均可导致常规 MRI 上表现相似的脑白质病变。本研究旨在比较这些异常，并寻找偏头痛的特定解剖学生物标志物。在液体衰减反转恢复 MRI 上对 17 例偏头痛患者和 15 例 MS 患者的幕上脑白质高信号（WMH）进行计数、体积分析和叶分布评估。我们发现，偏头痛 WMH 主要影响深部白质和皮质下 U 纤维，属于前循环，在额叶和顶叶更常见，各叶间平均大小无差异，且小于 MS。大多数 MS WMH 位于额叶，平均尺寸最小，而枕叶的 WMH 数量最少且最大。两组幕上 WMH 的表现模式不同；然而，在个别患者中，通过常规 MRI 进行 WMH 的准确鉴别诊断可能并不可能。
