Seneviratne Udaya, Chong Winston, Billimoria P H
Department of Neuroscience, Monash Medical Centre & Monash University, Clayton, VIC 3168, Australia.
Clin Neurol Neurosurg. 2013 Jul;115(7):1040-3. doi: 10.1016/j.clineuro.2012.10.033. Epub 2012 Nov 20.
Migraine is a recognised cause of brain white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI). However radiological characteristics of those in migraine are not well defined. We sought to study the radiological characteristics and factors associated with WMH in migraine.
Migraine patients who were investigated with MRI of the brain in the outpatient clinic were studied retrospectively. Two groups were delineated based on the presence or absence of WMH in MRI scans. The clinical and demographic characteristics between the two groups were compared to delineate the associations of WMH.
Forty four patients were studied, out of which 19 demonstrated WMH on MRI. Frontal lobe was involved in all subjects with WMH. Infratentorial hyperintensities were not seen in any. Subcortical and deep white matter was the commonest distribution while callosal and subcallosal lesions were very rare. Family history of migraine, increasing age, and increasing headache frequency emerged as significant associations of WMH in multivariable analysis.
There are characteristic radiological features and clinical associations of WMH in migraine.
偏头痛是磁共振成像（MRI）上脑白质高信号（WMH）的一个公认病因。然而，偏头痛患者脑白质高信号的影像学特征尚未明确界定。我们旨在研究偏头痛患者脑白质高信号的影像学特征及相关因素。
对门诊接受脑部MRI检查的偏头痛患者进行回顾性研究。根据MRI扫描中是否存在脑白质高信号划分出两组。比较两组患者的临床和人口统计学特征，以明确脑白质高信号的相关因素。
共研究了44例患者，其中19例在MRI上显示有脑白质高信号。所有有脑白质高信号的患者均累及额叶。幕下未见高信号。皮质下和深部白质是最常见的分布部位，而胼胝体和胼胝体下病变非常罕见。在多变量分析中，偏头痛家族史、年龄增长和头痛频率增加是脑白质高信号的显著相关因素。
偏头痛患者脑白质高信号具有特征性的影像学表现和临床相关性。
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