Wang Qianbin, Wang Qiguang, Wan Changxiu
School of Chemistry and Environment, Beihang University, Beijing, China.
An Acad Bras Cienc. 2012 Mar;84(1):9-16. doi: 10.1590/s0001-37652012000100003.
A novel biodegradable scaffold based on mimetic a natural bone tissue morphology with a porosity gradient structure was prepared in this paper. The result of surface morphology indicated that a graded porous structure was formed in the fabricated scaffold, where the dense layer (0%) was connected with the most porous layer (60%) by a middling porous layer (30%). To evaluate the degradability, graded porous scaffolds compared with homogeneous scaffolds were placed into a Tris-HCl buffer solution (pH = 7.4) for 28 days. It was found that both scaffolds presented the same degradation trend, and the graded porous structure did not change the original degradability of the scaffold. Moreover, the compressive strength of the graded porous scaffold was better than that of conventional homogeneous scaffold with the increase of degradation time, and the graded porous structure can enhanced the mechanical property of the scaffold. These findings suggest that this biodegradable and porosity-graded scaffold may be a new promising scaffold for loaded bone implant.
本文制备了一种基于模拟天然骨组织形态且具有孔隙率梯度结构的新型可生物降解支架。表面形态结果表明，在制备的支架中形成了梯度多孔结构，其中致密层（0%）通过中等孔隙率层（30%）与孔隙率最高的层（60%）相连。为了评估降解性，将梯度多孔支架与均匀支架一起置于Tris-HCl缓冲溶液（pH = 7.4）中28天。结果发现，两种支架呈现相同的降解趋势，且梯度多孔结构并未改变支架原有的降解性。此外，随着降解时间的增加，梯度多孔支架的抗压强度优于传统均匀支架，且梯度多孔结构可增强支架的力学性能。这些研究结果表明，这种可生物降解且具有孔隙率梯度的支架可能是一种用于负载型骨植入物的新型有前景的支架。
