实验性大鼠脑肿瘤的磁共振成像：组织病理学评估

Magnetic resonance imaging of experimental rat brain tumors: histopathological evaluation.

作者信息

Baba T, Moriguchi M, Natori Y, Katsuki C, Inoue T, Fukui M

机构信息

Department of Neurosurgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

出版信息

Surg Neurol. 1990 Dec;34(6):378-82. doi: 10.1016/0090-3019(90)90240-p.

DOI:10.1016/0090-3019(90)90240-p

PMID:2244301

Abstract

Using RG-C6 glioma-transplanted rats, we studied precontrast and postcontrast magnetic resonance imaging, extravasation of Evans blue, and histology. In all rats, tumor was enhanced with gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA). The necrotic portion in the tumor, however, was not enhanced. Hemorrhage and hydrocephalus were clearly visualized on both the precontrast and postcontrast images. Blood-brain barrier-disrupted areas stained with Evans blue and areas enhanced with Gd-DTPA on magnetic resonance imaging were nearly consistent. It is suggested that the mechanism of brain tumor enhancement with Gd-DTPA on magnetic resonance imaging is simply related to the degree of alteration of the blood-brain barrier. The Gd-DTPA-enhanced magnetic resonance imaging, even with low magnetic field, is useful for the evaluation of size, shape, and location of experimental rat brain tumors.

摘要

我们使用RG-C6胶质瘤移植大鼠，研究了对比剂注射前和注射后的磁共振成像、伊文思蓝外渗情况以及组织学。在所有大鼠中，肿瘤经钆喷酸葡胺（Gd-DTPA）增强。然而，肿瘤内的坏死部分未增强。在对比剂注射前和注射后的图像上均能清晰显示出血和脑积水。伊文思蓝染色的血脑屏障破坏区域与磁共振成像上Gd-DTPA增强的区域几乎一致。提示磁共振成像上Gd-DTPA增强脑肿瘤的机制仅与血脑屏障的改变程度有关。即使在低磁场下，Gd-DTPA增强磁共振成像也有助于评估实验大鼠脑肿瘤的大小、形状和位置。