Matsumura A, Shibata Y, Yamamoto T, Nakagawa K, Yasuda S, Nakajima S, Sakata I, Yoshizawa T, Nose T
Department of Neurosurgery, University of Tsukuba, Ibaraki.
Neurol Med Chir (Tokyo). 1997 Apr;37(4):327-31. doi: 10.2176/nmc.37.327.
A conjugate of manganese-metalloporphyrin and gadolinium (Gd)-diethylenetriaminepenta-acetic acid (Gd-ATN10) was developed as a tumor-specific enhancement agent for magnetic resonance (MR) imaging. Gd-ATN10 was evaluated in an experimental 9L gliosarcoma rat tumor model. T1-weighted MR imaging showed enhancement of the tumor which persisted for up to 24 hours. Gd concentration measurement by inductively coupled plasma atomic emission spectroscopy revealed the peak Gd concentration was reached after 30 minutes and Gd was retained in the blood and tumor up to 24 hours. There was no uptake of Gd in the normal brain and little in the skin. Gd-porphyrin derivatives are potentially useful agents for tumor diagnosis on MR imaging and for neutron capture therapy.
锰金属卟啉与钆（Gd）-二乙烯三胺五乙酸（Gd-ATN10）的共轭物被开发为一种用于磁共振（MR）成像的肿瘤特异性增强剂。在实验性9L胶质肉瘤大鼠肿瘤模型中对Gd-ATN10进行了评估。T1加权MR成像显示肿瘤增强，持续长达24小时。通过电感耦合等离子体原子发射光谱法进行的钆浓度测量显示，30分钟后达到钆浓度峰值，钆在血液和肿瘤中保留长达24小时。正常脑组织中没有钆摄取，皮肤中摄取很少。钆卟啉衍生物在MR成像肿瘤诊断和中子俘获治疗方面可能是有用的药物。
