Department of Pharmaceutics, School of Pharmacy, Fudan University, Zhangheng Road 826, Shanghai, PR China.
Curr Drug Metab. 2012 May 1;13(4):396-417. doi: 10.2174/138920012800166544.
Nanoemulsions are composed of nanoscale droplets of one immiscible liquid dispersed within another, which have been the focus of extensive research worldwide due to their solubilization and transportation capacity of both hydrophobic and hydrophilic active compounds with unique physical properties. In a broad sense, submicron-emulsion, microemulsion, self-microemulsifing drug delivery system, lipid emulsion and cholesterol-rich microemulsion (LDE) all belong to nanoemulsions. The review starts with a brief introduction to the definition, formulation rationale, and types of nanoemulaions, and focused on, by different administration routes such as the oral, intravenous, transdermal, ocular nasal and rectal routes, the absorption, disposition, pharmacokinetics properties of nanoemulsions.
纳米乳由一种不混溶液体的纳米级液滴分散在另一种液体中组成，由于其具有独特的物理性质，能够增溶和输送疏水性和亲水性活性化合物，因此引起了全球范围内的广泛研究。广义上，亚微米乳、微乳、自微乳给药系统、脂质体和富含胆固醇的微乳（LDE）都属于纳米乳。本综述首先简要介绍了纳米乳的定义、配方原理和类型，并通过不同的给药途径（如口服、静脉、透皮、眼部、鼻腔和直肠途径），重点介绍了纳米乳的吸收、分布和药代动力学性质。
