1Faculty of Agricultural Sciences, Department of Genetics and Biotechnology, Aarhus University, Blichers Allé 20, P.O. BOX 50, DK-8830 Tjele, Denmark.
Animal. 2010 Mar;4(3):417-24. doi: 10.1017/S1751731109991248.
Osteochondrosis is a growth disorder in the cartilage of young animals and is characterised by lesions found in the cartilage and bone. This study identified quantitative trait loci (QTLs) associated with six osteochondrosis lesion traits in the elbow joint of finishing pigs. The traits were: thickening of the cartilage, lesion in the subchondral bone, irregular cartilage surface, fissure under the cartilage, an irregular sagittal central groove and depression of the proximal edge of the radius. The study comprised 7172 finishing pigs from crossing 12 Duroc boars with 600 crossbred Landrace × Large White sows and included 462 single nucleotide polymorphism markers. The results showed 18 QTLs exceeding the 5% genome-wide threshold. The QTLs associated with lesions in the medial part of the condylus humeri (assumed to be the four main osteochondrosis traits) were, in most cases, at common locations, whereas the QTLs associated with depression of the proximal edge of the radius in general were on the same chromosomes but at separate locations. The detected QTLs explain a large part of the genetic variation, which is promising for incorporating osteochondrosis into a breeding programme using marker-assisted selection.
骨软骨病是一种发生在幼小动物软骨中的生长障碍，其特征是软骨和骨中的病变。本研究鉴定了与肥育猪肘关节 6 种骨软骨病病变特征相关的数量性状位点（QTL）。这些特征包括：软骨增厚、软骨下骨病变、软骨表面不规则、软骨下裂隙、矢状中央沟不规则和桡骨近端边缘凹陷。该研究包括来自 12 头杜洛克公猪与 600 头杂交长白×大白母猪杂交的 7172 头肥育猪，包括 462 个单核苷酸多态性标记。结果显示，有 18 个 QTL 超过了全基因组 5%的阈值。与肱骨滑车内侧病变相关的 QTL（假定为主要的 4 种骨软骨病病变）在大多数情况下位于相同的位置，而与桡骨近端边缘凹陷相关的 QTL 通常位于同一染色体上，但位于不同的位置。所检测到的 QTL 解释了大部分遗传变异，这对于利用标记辅助选择将骨软骨病纳入育种计划是有希望的。
