老龄驴群胃溃疡剖检调查：流行情况、病变描述及危险因素。

Necropsy survey of gastric ulcers in a population of aged donkeys: prevalence, lesion description and risk factors.

机构信息

Veterinary Department, The Donkey Sanctuary, Sidmouth, Devon EX10 0NU, UK.

出版信息

Animal. 2009 Feb;3(2):287-93. doi: 10.1017/S1751731108003480.

Abstract

There is no information about the prevalence of gastric ulceration in donkeys or potential risk factors for its presence in donkeys. The donkey is a stoic, hardy animal that has not previously been thought to suffer from this disease. However, gastric ulceration was found to be a problem in a population of non-working UK donkeys resident at the Donkey Sanctuary and its prevalence was estimated by examining necropsy data over a 2-year period during 2005 to 2006. Associations with clinical and management factors were determined. In total, 426 donkeys were examined at necropsy to determine the presence of gastric ulceration. Lesions were described and scored according to a four-point scale. Management and clinical data from these donkeys were analysed to identify potential risk factors for the presence of gastric ulceration. Terminal blood samples were also studied to determine whether animals were exhibiting hyperlipaemia prior to death. Results showed that 41% (n = 174) of the donkeys studied had evidence of gastric ulceration at necropsy. Most (49%) of the ulcers were of a medium size (area of 2 cm2 - <10 cm2) and the most common site for ulcers was the margo plicatus. Of the donkeys examined, 18% had hyperlipaemia prior to or death or euthanasia and this was a risk factor for donkeys developing gastric ulceration; 62% of hyperlipaemia cases also displayed gastric ulceration (P < 0.001). Kidney disease was a potential risk factor (P = 0.02), with 74% of these animals having gastric ulceration. Donkeys that died or were euthanased due to respiratory disease were at a decreased risk of developing ulceration (P = 0.01) Donkeys fed a carbohydrate-based diet were more likely (P < 0.001) to have gastric ulceration than those fed a fibre-only diet, with 55% having gastric ulceration compared with 33% in the fibre-only group. This study has shown that gastric ulceration is commonly observed in donkeys at necropsy and may be extensive.

摘要

目前尚无有关驴胃溃疡流行情况或其潜在发病因素的信息。驴是一种坚韧、 hardy 的动物，以前人们认为它不会患这种疾病。然而，在英国非工作驴居住的多塞特唐斯动物保护区（Donkey Sanctuary）的一个驴群中发现了胃溃疡问题，在 2005 年至 2006 年期间，通过检查尸检数据，对其患病率进行了估计。确定了与临床和管理因素的关联。总共有 426 头驴进行了尸检以确定是否存在胃溃疡。根据四点量表对病变进行了描述和评分。对这些驴的管理和临床数据进行了分析，以确定胃溃疡发生的潜在危险因素。还研究了终末期血液样本，以确定动物在死亡前是否表现出高脂血症。结果表明，41%（n=174）的研究驴在尸检时存在胃溃疡证据。大多数（49%）溃疡为中等大小（面积为 2 cm2-<10 cm2），最常见的溃疡部位是皱褶缘。在检查的驴中，18%的驴在死亡或安乐死之前或之前有高脂血症，这是驴发生胃溃疡的危险因素；高脂血症病例中有 62%（P<0.001）还显示出胃溃疡。肾病是一个潜在的危险因素（P=0.02），其中 74%的动物有胃溃疡。由于呼吸疾病而死亡或安乐死的驴发生溃疡的风险降低（P=0.01）。饲喂基于碳水化合物的饮食的驴比仅饲喂纤维的驴更有可能（P<0.001）发生胃溃疡，前者中有 55%发生胃溃疡，而后者中只有 33%。本研究表明，在尸检时，驴的胃溃疡很常见，而且可能很严重。