Morimoto Y, Conroy S M, Ollberding N J, Kim Y, Lim U, Cooney R V, Franke A A, Wilkens L R, Hernandez B Y, Goodman M T, Henderson B E, Kolonel L N, Le Marchand L, Maskarinec G
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Department of Population Health Research, Alberta Health Services-Cancer Care, Calgary, Canada.
Int J Obes (Lond). 2014 Nov;38(11):1416-22. doi: 10.1038/ijo.2014.25. Epub 2014 Feb 13.
Ethnic disparities in metabolic disease risk may be the result of differences in circulating adipokines and inflammatory markers related to ethnic variations in obesity and body fat distribution.
SUBJECTS/METHODS: In a cross-sectional design, we compared serum levels of leptin, adiponectin, C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in control subjects (321 men and 930 women) from two nested case-control studies conducted within the Multiethnic Cohort Study consisting of whites, Japanese Americans (JA), Latinos, African Americans (AA) and Native Hawaiians (NH). General linear models were applied to evaluate ethnic differences in log-transformed serum biomarker levels before and after adjusting for body mass index (BMI) at cohort entry.
In comparison to whites, significant ethnic differences were observed for all biomarkers except TNF-α. JA men and women had significantly lower leptin and CRP levels than whites, and JA women also had lower adiponectin levels. Leptin was significantly higher in AA women (P < 0.01), adiponectin was significantly lower in AA men and women (P = 0.02 and P < 0.001), and CRP and IL-6 were significantly higher in AA men and women. Lower adiponectin (P < 0.0001) and CRP (P = 0.03) levels were the only biomarkers in NH women that differed from whites; no statistically significant differences were seen for NH men and for Latino men and women. When adjusted for BMI at cohort entry, the differences between the lowest and the highest values across ethnic groups decreased for all biomarkers except adiponectin in men indicating that ethnic differences were partially due to weight status.
These findings demonstrate the ethnic variations in circulating adipokine and CRP levels before and after adjustment for BMI. Given the limitation of BMI as a general measure of obesity, further investigation with visceral and subcutaneous adiposity measures are warranted to elucidate ethnicity-related differences in adiposity in relation to disparities in obesity-related disease risk.
代谢疾病风险的种族差异可能是由于与肥胖及体脂分布的种族差异相关的循环脂肪因子和炎症标志物不同所致。
受试者/方法：在一项横断面设计中，我们比较了来自多民族队列研究中两项嵌套病例对照研究的对照受试者（321名男性和930名女性）的血清瘦素、脂联素、C反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平，该队列研究包括白人、日裔美国人（JA）、拉丁裔、非裔美国人（AA）和夏威夷原住民（NH）。应用一般线性模型评估在队列入组时调整体重指数（BMI）前后对数转换后的血清生物标志物水平的种族差异。
与白人相比，除TNF-α外，所有生物标志物均观察到显著的种族差异。JA男性和女性的瘦素和CRP水平显著低于白人，JA女性的脂联素水平也较低。AA女性的瘦素显著更高（P<0.01），AA男性和女性的脂联素显著更低（P = 0.02和P<0.001），AA男性和女性的CRP和IL-6显著更高。脂联素水平较低（P<0.0001）和CRP水平较低（P = 0.03）是NH女性中与白人不同的唯一生物标志物；NH男性以及拉丁裔男性和女性未观察到统计学上的显著差异。在队列入组时调整BMI后，除男性脂联素外，所有生物标志物在不同种族组中最低值和最高值之间的差异均减小，这表明种族差异部分归因于体重状况。
这些发现证明了在调整BMI前后循环脂肪因子和CRP水平存在种族差异。鉴于BMI作为肥胖一般测量指标的局限性，有必要进一步采用内脏和皮下脂肪测量方法进行研究，以阐明与肥胖相关疾病风险差异相关的种族相关脂肪差异。
