Frei B, Stocker R, England L, Ames B N
Department of Biochemistry, University of California, Berkeley 94720.
Adv Exp Med Biol. 1990;264:155-63. doi: 10.1007/978-1-4684-5730-8_24.
Ascorbate is the only endogenous antioxidant in plasma that can completely protect the lipoproteins from detectable peroxidative damage induced by aqueous peroxyl radicals and the oxidants released from activated PMNs. In contrast to aqueous oxidants, lipid-soluble peroxyl radicals unsparingly induce detectable peroxidative damage to plasma lipids. However, under these conditions, too, ascorbate appears to belong to the first line of antioxidant defense. Our findings strongly suggest that pathologically relevant lipid hydroperoxide formation consequent to acute or chronic leukocyte activation can be prevented by ascorbate supplementation, provided no free metal catalysts are present. Ascorbate should prove very helpful in the treatment and prevention of diseases and degenerative processes caused by oxidative stress.
抗坏血酸盐是血浆中唯一能完全保护脂蛋白免受水相过氧自由基和活化的多形核白细胞释放的氧化剂所引起的可检测到的过氧化损伤的内源性抗氧化剂。与水相氧化剂不同，脂溶性过氧自由基会无差别地对血浆脂质造成可检测到的过氧化损伤。然而，在这些情况下，抗坏血酸盐似乎也属于抗氧化防御的第一线。我们的研究结果有力地表明，在不存在游离金属催化剂的情况下，补充抗坏血酸盐可以预防急性或慢性白细胞活化导致的与病理相关的脂质过氧化氢的形成。抗坏血酸盐在治疗和预防由氧化应激引起的疾病和退行性过程中应该会非常有帮助。
