Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China.
Phytomedicine. 2012 Apr 15;19(6):545-50. doi: 10.1016/j.phymed.2011.12.006. Epub 2012 Mar 23.
Our previous study found that curcumin, a major active component of turmeric, could ameliorate ethanol-induced hepatocytes oxidative stress in vitro. The objective of this work was to investigate the effect of curcumin on chronic alcoholic liver disease (ALD) in vivo. Ethanol-exposed (2.4g/kg/day ethanol for the initial 4 weeks and 4g/kg/day for another 2 weeks) Balb/c mice were simultaneously treated with curcumin for 6 weeks. The results showed that curcumin attenuated ethanol-induced histopathological changes of the liver and ameliorated the evident release of cellular alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Ethanol exposure resulted in reactive oxygen species (ROS) generation, malondialdehyde (MDA) elevation, glutathione (GSH) depletion and antioxidant defense system impairment, which were significantly reversed by curcumin treatment. In conclusion, curcumin provided protection against chronic ALD and the mechanism might be related to the alleviation of oxidative damage.
我们之前的研究发现，姜黄素是姜黄的主要活性成分之一，能够改善体外乙醇诱导的肝细胞氧化应激。本研究旨在探讨姜黄素对慢性酒精性肝病（ALD）的体内作用。用乙醇（最初 4 周 2.4g/kg/天，随后 2 周 4g/kg/天）暴露的 Balb/c 小鼠同时用姜黄素处理 6 周。结果表明，姜黄素减轻了乙醇诱导的肝脏组织病理学变化，并改善了明显的细胞丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）释放。乙醇暴露导致活性氧（ROS）生成、丙二醛（MDA）升高、谷胱甘肽（GSH）耗竭和抗氧化防御系统受损，这些均被姜黄素处理显著逆转。总之，姜黄素对慢性 ALD 有保护作用，其机制可能与减轻氧化损伤有关。
