Department of Internal Medicine, St. Vincent's Hospital, Connecticut, 2800, Main Street, Bridgeport, CT 06606, USA.
Med Oncol. 2012 Dec;29(4):2661-3. doi: 10.1007/s12032-012-0219-7. Epub 2012 Mar 25.
Primary lung adenocarcinoma is a rare entity in the pediatric population, especially in the absence of an underlying congenital pulmonary airway malformation. Primary lung malignancies in pediatric patients are rare and constitute 0.2% of all childhood malignancies. EGFR mutations and congenital airway malformations have been identified as etiological factors in the development of precancerous lesions that eventually progress to malignancy. The availability of genome sequencing and advanced imaging has made it possible to associate primary lung adenocarcinoma with mutations and structural malformations. Early diagnosis with the help of these techniques may result in surgical resection during early stages of the disease and possibly provide definitive treatment. Development of lung adenocarcinoma in pediatric patients in the absence of the above factors has been recorded anecdotally. It is possible that these patients may harbor a yet unknown set of mutations and recording this cases and preserving their tissues is of vital importance in the detection of these yet unknown etiologies.
儿童原发性肺腺癌较为罕见，尤其是在不存在先天性肺气道畸形的情况下。儿童原发性肺部恶性肿瘤较为罕见，占所有儿童恶性肿瘤的 0.2%。EGFR 突变和先天性气道畸形已被确定为癌前病变发展为恶性肿瘤的病因。基因组测序和先进成像技术的出现，使得将原发性肺腺癌与突变和结构畸形联系起来成为可能。借助这些技术进行早期诊断，可能会在疾病早期进行手术切除，并可能提供明确的治疗方法。在没有上述因素的情况下，儿童患者中出现肺腺癌的情况已有报道。这些患者可能携带一组尚未被发现的突变，因此记录这些病例并保存其组织对于发现这些未知病因至关重要。
