Hammen C, Burge D, Burney E, Adrian C
Department of Psychology, UCLA 90024.
Arch Gen Psychiatry. 1990 Dec;47(12):1112-7. doi: 10.1001/archpsyc.1990.01810240032006.
School-age children of unipolar depressed, bipolar, chronically medically ill, or normal women were diagnosed every 6 months for up to 3 years. Offspring of unipolar women had the highest rates of disorder at all evaluations, but children of bipolar and medically ill mothers also experienced significant rates of disorder. Observing diagnoses from both past lifetime and prospective follow-up assessments, it appeared that most children who had diagnoses had onsets in preadolescence and continued a chronic or intermittent course of disorder. Thus, risk to offspring of ill mothers is not transitory and indicates a pernicious course that commonly includes effective disorders alone or in combination with behavior and anxiety disorders.
对单相抑郁症、双相情感障碍、患有慢性疾病或正常女性的学龄儿童，每6个月进行一次诊断，为期最长3年。在所有评估中，单相抑郁症女性的后代患精神障碍的比率最高，但双相情感障碍和患有慢性疾病母亲的孩子也有相当高的精神障碍发生率。从过去终生诊断和前瞻性随访评估来看，似乎大多数被诊断出患有精神障碍的儿童在青春期前就已发病，并持续患有慢性或间歇性精神障碍。因此，患病母亲的后代所面临的风险并非短暂的，而是表明存在一种有害的病程，通常单独包括情感障碍，或与行为和焦虑障碍合并出现。
