Lee Hyeon-Ah, Kim Ji-Sun, Lee Yeon-Jung, Heo Nam-Hun, Shim Se-Hoon, Kwon Young-Joon
Department of Psychiatry, Cheonan Hospital, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.
Department of Psychiatry, Seoul Hospital, College of Medicine, Soonchunhyang University, Seoul, Republic of Korea.
Psychiatry Investig. 2018 Dec;15(12):1135-1143. doi: 10.30773/pi.2018.10.22.1. Epub 2018 Oct 26.
The aim of this study was to evaluate differences in psychopathology between offspring of parents with bipolar I disorder (BP-I) and those with bipolar II disorder (BP-II).
The sample included 201 offspring between 6 and 17 years of age who had at least one parent with BP-I or BP-II. The offspring were diagnostically evaluated using the Korean Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. Psychopathology and Clinical characteristics were evaluated, including lifetime DSM-5 diagnoses, depression, and childhood trauma. Lifetime DSM-5 diagnoses were also compared between schoolchildren aged 6 to 11 years and adolescents aged 12 to 17 years.
In lifetime DSM-5 diagnoses, offspring of parents with BP-I had significantly increased risk of developing MDD and BP-I than those with BP-II. Regarding clinical characteristics, ADHD rating scale and childhood trauma scale were significantly higher in offspring of parents with BP-I than that in those with BP-II.
The present study supports that BP-I may be etiologically distinct from BP-II by a possible genetic liability. Our findings indicate that additional research related to bipolar offspring is needed to enhance understanding of differences between BP-I and BP-II.
本研究旨在评估患有I型双相情感障碍（BP-I）的父母的后代与患有II型双相情感障碍（BP-II）的父母的后代在精神病理学方面的差异。
样本包括201名6至17岁的后代，他们至少有一位父母患有BP-I或BP-II。使用韩国版《儿童情感障碍和精神分裂症评定量表-目前和终生版》对后代进行诊断评估。评估了精神病理学和临床特征，包括终生DSM-5诊断、抑郁和童年创伤。还比较了6至11岁学龄儿童和12至17岁青少年的终生DSM-5诊断。
在终生DSM-5诊断中，患有BP-I的父母的后代患重度抑郁症（MDD）和BP-I的风险比患有BP-II的父母的后代显著增加。关于临床特征，患有BP-I的父母的后代的注意力缺陷多动障碍（ADHD）评定量表和童年创伤量表显著高于患有BP-II的父母的后代。
本研究支持BP-I在病因上可能与BP-II不同，存在可能的遗传易感性。我们的研究结果表明，需要进行更多与双相情感障碍后代相关的研究，以加深对BP-I和BP-II之间差异的理解。
