Department of Anesthesiology and Critical Care Medicine, University of Muenster, Muenster, Germany.
Int Rev Immunol. 2012 Apr;31(2):104-18. doi: 10.3109/08830185.2012.668982.
Recruitment of leukocytes into inflamed tissue is a key component of the immune system. The activation of integrins on leukocytes is required for their recruitment into the inflamed tissue. Btk is a cytoplasmic nonreceptor tyrosine kinase belonging to the Tec-kinase family. It plays a key role in B-cell development and function, and recently published studies revealed important roles of Btk in myeloid cells. Btk might be activated through a variety of receptors leading to activation of integrins as the pivotal element in leukocyte recruitment. This review focuses on the role of Btk in B-lymphocyte homing and in neutrophil recruitment.
白细胞募集到炎症组织是免疫系统的一个关键组成部分。白细胞整合素的激活是它们募集到炎症组织所必需的。Btk 是一种细胞质非受体酪氨酸激酶，属于 Tec-激酶家族。它在 B 细胞的发育和功能中起着关键作用，最近发表的研究揭示了 Btk 在髓样细胞中的重要作用。Btk 可能通过多种受体被激活，导致整合素的激活，作为白细胞募集的关键因素。这篇综述重点介绍了 Btk 在 B 淋巴细胞归巢和中性粒细胞募集中的作用。
