Pharmacyclics, Inc., Sunnyvale , California , USA.
Int Rev Immunol. 2012 Apr;31(2):119-32. doi: 10.3109/08830185.2012.664797.
BTK is a kinase that functions downstream of multiple receptors in various hematologic cells. This review focuses on BTK-dependent pathways that are likely to be involved in maintaining the malignant phenotype in B-cell lymphomas and leukemias. Survival of various B-cell malignancies requires BTK-dependent signals from the B-cell antigen receptor. Survival is also dependent on malignant cells homing to and interacting with lymphoid microenvironments, and these interactions are also BTK-dependent due its role in signaling downstream of chemokine and innate immune receptors. The potential for therapeutic targeting of BTK is currently being tested in clinical settings.
BTK 是一种激酶，在多种血液细胞中的多种受体下游发挥作用。本综述重点介绍了 BTK 依赖性途径，这些途径可能参与维持 B 细胞淋巴瘤和白血病中的恶性表型。各种 B 细胞恶性肿瘤的存活需要来自 B 细胞抗原受体的 BTK 依赖性信号。存活还依赖于恶性细胞归巢并与淋巴微环境相互作用，并且由于其在趋化因子和先天免疫受体下游信号转导中的作用，这些相互作用也依赖于 BTK。目前正在临床环境中测试针对 BTK 的治疗靶向的可能性。
