Imura Yuki, Yoshimura Etsuro, Sato Kiichi
Department of Applied Biological Chemistry, School of Agricultural and Life Science, The University of Tokyo, Japan.
Anal Sci. 2012;28(3):197-9. doi: 10.2116/analsci.28.197.
A micro total bioassay system that mimics physiological processes was developed as a means of evaluating orally administered drugs. A new feature accounting for gastrointestinal digestion was added to the previous system, which consists of microintestine, microliver, and target components. The artificial micro-gastrointestinal tract employs synthetic digestive juices. The system could correctly assay the overall digestive properties of ingested anticancer agents, i.e., the stability during digestive processes, as well as intestinal absorption, hepatic metabolism, and bioactivity toward target cells.
开发了一种模拟生理过程的微型全生物测定系统，作为评估口服药物的一种手段。在先前由微肠道、微肝脏和靶标成分组成的系统中增加了一个考虑胃肠道消化的新特性。人工微型胃肠道采用合成消化液。该系统能够正确测定摄入的抗癌药物的整体消化特性，即消化过程中的稳定性，以及肠道吸收、肝脏代谢和对靶细胞的生物活性。
