Tea Research Institute, Zhejiang University, Hangzhou 310058, PR China.
Phytother Res. 2013 Jan;27(1):62-5. doi: 10.1002/ptr.4693. Epub 2012 Mar 26.
Hypercholesterolaemia is one of the risk factors for atherosclerosis and subsequent cardiovascular disease. Here, we investigated the effects of dietary supplementation with Ilex latifolia or green tea (Camellia sinensis) on the levels of plasma total cholesterol, high-density lipoprotein cholesterol and circulating immune complexes in Sprague Dawley rats fed with a high-cholesterol diet. We demonstrated that daily administration by gavage of I. latifolia or C. sinensis at doses of 1.0 or 2.0 g/kg body weight for 30 days resulted in a significant decrease in plasma total cholesterol levels and circulating immune complexes and an increase in high-density lipoprotein cholesterol in rats fed with a high-cholesterol diet compared with levels in the high-cholesterol diet control group. C. sinensis was more effective than I. latifolia. I. latifolia and C. sinensis could be used as food supplements to protect against the development of hypercholesterolaemia.
高胆固醇血症是动脉粥样硬化和随后的心血管疾病的危险因素之一。在这里，我们研究了伊莱克斯·拉蒂福拉或绿茶（茶）补充饮食对给予高胆固醇饮食的斯普拉格 - 道利大鼠血浆总胆固醇，高密度脂蛋白胆固醇和循环免疫复合物水平的影响。我们证明，每天通过灌胃给予 1.0 或 2.0 g / kg 体重的剂量 30 天，与高胆固醇饮食对照组相比，高胆固醇饮食大鼠的血浆总胆固醇水平和循环免疫复合物显著降低，高密度脂蛋白胆固醇升高。与伊莱克斯·拉蒂福拉相比，绿茶更为有效。伊莱克斯·拉蒂福拉和绿茶可用作食品补充剂，以预防高胆固醇血症的发展。
