Graduate Institute of Biotechnology, National Chung Hsing University, Taichung 402, Taiwan.
Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 110, Taiwan.
Nutrients. 2022 Nov 4;14(21):4665. doi: 10.3390/nu14214665.
and both contain unique polyphenols called phlorotannins. Phlorotannins reportedly possess various pharmacological activities. A previous study reported that the activity of phlorotannin is strongly correlated with the normalization of metabolic function, and phlorotannins are extremely promising nutrients for use in the treatment of metabolic syndrome. To date, no study has explored the antihyperlipidemic effects of phlorotannins from and in animal models. Therefore, in the present study, we investigated the effects of phlorotannins using a rat model of high-energy diet (HED)-induced hyperlipidemia. The results showed that the rats that were fed an HED and treated with phlorotannin-rich extract from and had significantly lower serum fasting blood sugar (FBS), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol (TC), triacylglyceride (TG) and free fatty acids (FFAs) levels and hepatic TG level and had higher serum insulin, high-density lipoprotein cholesterol (HDL-C) levels and lipase activity in their fat tissues than in the case with the rats that were fed the HED alone. A histopathological analysis revealed that phlorotannin-rich extract could significantly reduce the size of adipocytes around the epididymis. In addition, the rats treated with phlorotannin-rich extract had significantly lowered interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) levels and increased superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities than did those in the HED group. These results suggested that the phlorotannin-rich extract stimulated lipid metabolism and may have promoted lipase activity in rats with HED-induced hyperlipidemia. Our results indicated that and , marine algae typically used as health foods, have strong antihyperlipidemic effects and may, therefore, be useful for preventing atherosclerosis. These algae may be incorporated into antihyperlipidemia pharmaceuticals and functional foods.
和 都含有独特的多酚类物质，称为岩藻黄质。据报道，岩藻黄质具有各种药理活性。先前的一项研究报告称，岩藻黄质的活性与代谢功能的正常化密切相关，岩藻黄质是治疗代谢综合征极有前途的营养物质。迄今为止，尚无研究探讨 和 中的岩藻黄质在动物模型中的抗高血脂作用。因此，在本研究中，我们使用高脂肪饮食（HED）诱导的高血脂大鼠模型研究了岩藻黄质的作用。结果表明，喂食 HED 并接受 和 岩藻黄质丰富提取物治疗的大鼠的血清空腹血糖（FBS）、天门冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、总胆固醇（TC）、三酰甘油（TG）和游离脂肪酸（FFA）水平以及肝 TG 水平明显降低，血清胰岛素、高密度脂蛋白胆固醇（HDL-C）水平和脂肪组织中的脂肪酶活性升高，而单独喂食 HED 的大鼠则没有这些变化。组织病理学分析表明，岩藻黄质丰富的提取物可以显著减小附睾周围脂肪细胞的大小。此外，与 HED 组相比，用岩藻黄质丰富的提取物治疗的大鼠的白细胞介素 6（IL-6）和肿瘤坏死因子-α（TNF-α）水平降低，超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPX）活性升高。这些结果表明，岩藻黄质丰富的提取物刺激了脂质代谢，并可能促进了 HED 诱导的高血脂大鼠的脂肪酶活性。我们的结果表明， 和 ，通常用作保健品的海洋藻类，具有很强的抗高血脂作用，因此可能有助于预防动脉粥样硬化。这些藻类可以被纳入抗高血脂药物和功能性食品中。
