Danish Headache Centre, Department of Neurology at Glostrup Hospital, Ndr. Ringvej 57, 2600 Glostrup, Denmark.
Cephalalgia. 2012 May;32(7):578-80. doi: 10.1177/0333102412441719. Epub 2012 Mar 26.
The pharmaceutical industry shows a decreasing interest in the development of drugs for migraine. One of the reasons for this could be the lack of reliable animal models for studying the effect of acute and prophylactic migraine drugs. The infusion of glyceryl trinitrate (GTN) is the best validated and most studied human migraine model. Several attempts have been made to transfer this model to animals. The different variants of this model are discussed as well as other recent models.
制药行业对偏头痛药物的开发兴趣逐渐减弱。造成这种情况的原因之一可能是缺乏可靠的动物模型来研究急性和预防性偏头痛药物的效果。甘油三硝酸酯（GTN）输注是经过最好验证和研究最多的人类偏头痛模型。已经有几种尝试将这种模型转移到动物身上。本文讨论了该模型的不同变体以及其他最近的模型。
