Department of Radiology, Children's Hospital Los Angeles, Keck School of Medicine, CA 90027, USA.
AJR Am J Roentgenol. 2012 Apr;198(4):909-13. doi: 10.2214/AJR.11.7488.
The objective of our study was to determine whether the depiction of brown adipose tissue (BAT) in PET/CT studies of pediatric patients with lymphoma is related to disease status.
The PET/CT studies of 31 pediatric patients (17 boys and 14 girls) with Hodgkin or non-Hodgkin lymphoma were reviewed, and the prevalence of metabolically active BAT at diagnosis and the prevalence of BAT when there was no evidence of disease were compared.
The percentage of PET/CT studies depicting BAT was greater when there was no evidence of disease than at diagnosis (10% vs 77%, respectively; p < 0.001). The McNemar test indicated a strong inverse correlation between the presence of disease and the presence of BAT (p < 0.001). This correlation was noted when all subjects were examined together and when subjects with Hodgkin lymphoma and those with non-Hodgkin lymphoma were analyzed separately (p < 0.001 and < 0.05, respectively). When baseline and follow-up PET/CT scans for all patients were analyzed for the presence of BAT using conditional logistic regression, both the season when the study was performed and disease status independently predicted BAT: The winter months positively predicted BAT and the presence of lymphoma was negatively correlated with the depiction of BAT on PET/CT. Age, sex, treatment, and weight did not provide additional information when added to the model.
The knowledge that BAT is a predictor of disease status should contribute to the correct analysis of PET/CT studies in children with lymphoma.
我们研究的目的是确定儿童淋巴瘤患者 PET/CT 研究中棕色脂肪组织（BAT）的描述是否与疾病状态有关。
回顾了 31 例儿童霍奇金或非霍奇金淋巴瘤患者的 PET/CT 研究，并比较了诊断时代谢活跃的 BAT 的患病率和无疾病证据时 BAT 的患病率。
无疾病证据的 PET/CT 研究中描绘 BAT 的百分比大于诊断时（分别为 10%和 77%；p <0.001）。McNemar 检验表明，疾病的存在与 BAT 的存在之间存在强烈的反比关系（p <0.001）。当一起检查所有受试者时，以及当分析霍奇金淋巴瘤和非霍奇金淋巴瘤患者时，都观察到这种相关性（均为 p <0.001 和 <0.05）。当使用条件逻辑回归分析所有患者的基线和随访 PET/CT 扫描以确定 BAT 的存在时，研究进行的季节和疾病状态独立地预测了 BAT：冬季月份阳性预测 BAT，而淋巴瘤的存在与 PET/CT 上 BAT 的描绘呈负相关。当将年龄、性别、治疗和体重添加到模型中时，它们并不能提供额外的信息。
了解 BAT 是疾病状态的预测因素，应该有助于正确分析儿童淋巴瘤患者的 PET/CT 研究。
