Department of Radiology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Am J Clin Nutr. 2012 May;95(5):1144-9. doi: 10.3945/ajcn.111.030650. Epub 2012 Mar 28.
Although the accumulation of white adipose tissue (WAT) is a risk factor for disease, brown adipose tissue (BAT) has been suggested to have a protective role against obesity.
We studied whether changes in BAT were related to changes in the amounts of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in children treated for malignancy.
We examined the effect of BAT activity on weight, SAT, and VAT in 32 pediatric patients with cancer whose positron emission tomography-computed tomography (PET-CT) scans at diagnosis showed no BAT activity. Changes in weight, SAT, and VAT from diagnosis to remission for children with metabolically active BAT at disease-free follow-up (BAT+) were compared with those in children without visualized BAT when free of disease (BAT-).
Follow-up PET-CT studies (4.7 ± 2.4 mo later) after successful treatment of the cancer showed BAT+ in 19 patients but no active BAT (BAT-) in 13 patients. BAT+ patients, in comparison with BAT- patients, gained significantly less weight (3.3 ± 6.6% compared with 11.0 ± 11.6%; P = 0.02) and had significantly less SAT (18.2 ± 26.5% compared with 67.4 ± 71.7%; P = 0.01) and VAT (22.6 ± 33.5% compared with 131.6 ± 171.8%; P = 0.01) during treatment. Multiple regression analysis indicated that the inverse relations between BAT activation and measures of weight, SAT, and VAT persisted even after age, glucocorticoid treatment, and the season when the PET-CT scans were obtained were accounted for.
The activation of BAT in pediatric patients undergoing treatment of malignancy is associated with significantly less adipose accumulation. This trial was registered at clinicaltrials.gov as NCT01517581.
尽管白色脂肪组织（WAT）的堆积是疾病的一个危险因素，但棕色脂肪组织（BAT）被认为对肥胖具有保护作用。
我们研究了在接受恶性肿瘤治疗的儿童中，BAT 的变化是否与皮下脂肪组织（SAT）和内脏脂肪组织（VAT）的变化有关。
我们检查了 32 名患有癌症的儿科患者的 BAT 活性对体重、SAT 和 VAT 的影响，这些患者在诊断时的正电子发射断层扫描-计算机断层扫描（PET-CT）扫描中没有显示 BAT 活性。在疾病无进展随访时（BAT+）显示 BAT 代谢活跃的儿童与疾病无进展时（BAT-）未发现 BAT 的儿童相比，从诊断到缓解期间体重、SAT 和 VAT 的变化。
在癌症成功治疗后（4.7 ± 2.4 个月后）进行的后续 PET-CT 研究显示，19 名患者有 BAT+，而 13 名患者无活跃的 BAT（BAT-）。与 BAT-患者相比，BAT+患者体重增加明显较少（3.3 ± 6.6%比 11.0 ± 11.6%；P = 0.02），SAT（18.2 ± 26.5%比 67.4 ± 71.7%；P = 0.01）和 VAT（22.6 ± 33.5%比 131.6 ± 171.8%；P = 0.01）减少明显。多元回归分析表明，即使考虑到年龄、糖皮质激素治疗和获得 PET-CT 扫描的季节，BAT 激活与体重、SAT 和 VAT 指标之间的反比关系仍然存在。
在接受恶性肿瘤治疗的儿科患者中，BAT 的激活与脂肪堆积明显减少有关。该试验在 clinicaltrials.gov 上注册为 NCT01517581。
