Beck S A, Groundwater P, Barton C, Tisdale M J
Cancer Research Campaign Experimental Chemotherapy Group, Pharmaceutical Sciences Institute, Aston University, Birmingham.
Br J Cancer. 1990 Nov;62(5):822-5. doi: 10.1038/bjc.1990.385.
The effect of chemotherapy on the serum lipid mobilising activity of a group of cancer patients with or without weight loss has been determined. The pre-treatment level of serum lipolytic activity in all cancer patients, with or without weight loss, was higher than normal controls (0.22 +/- 0.01 versus 0.06 +/- 0.01 mumols glycerol released ml-1 serum respectively). The pre-treatment levels of lipid mobilising activity in the patients serum was proportional to the extent of weight loss (correlation coefficient 0.81), if the extent of weight loss was small (less than 14 kg). Patients who showed a positive response to chemotherapy also showed a decrease in their plasma levels of lipolytic activity, while a patient who showed no response to therapy also showed no change in the serum lipolytic activity. There was no correlation between the serum lipolytic activity and response to megestrol acetate, a synthetic orally active progestogen, which is currently under investigation as an anticachectic agent. Serum from cancer patients showed lipolytic activity which was retained on a DEAE cellulose column and eluted by a salt gradient, in contrast with normal controls. Response to chemotherapy was associated with a decrease of the retained material, although the profile did not return to the normal state. These results need confirmation in a larger group of patients using more specific methods to determine tumour lipolytic activity, but suggest that it may be possible to monitor response to therapy by measurement of the serum lipolytic activity.
已确定化疗对一组有或无体重减轻的癌症患者血清脂质动员活性的影响。所有有或无体重减轻的癌症患者治疗前的血清脂解活性水平均高于正常对照组（分别为0.22±0.01与0.06±0.01μmol甘油释放/ml血清）。如果体重减轻程度较小（小于14kg），患者血清中脂质动员活性的治疗前水平与体重减轻程度成正比（相关系数0.81）。对化疗有阳性反应的患者其血浆脂解活性水平也降低，而对治疗无反应的患者血清脂解活性也无变化。血清脂解活性与目前作为抗恶病质药物正在研究的合成口服活性孕激素醋酸甲地孕酮的反应之间无相关性。与正常对照组相比，癌症患者的血清显示出脂解活性，该活性保留在DEAE纤维素柱上并通过盐梯度洗脱。对化疗的反应与保留物质的减少有关，尽管其图谱未恢复到正常状态。这些结果需要在更大规模的患者群体中使用更具体的方法来确定肿瘤脂解活性进行证实，但表明通过测量血清脂解活性可能监测对治疗的反应。
