Naugler C T, Halperin S A
Departments of Pediatrics, Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia.
Can J Infect Dis. 1998 Mar;9(2):83-6. doi: 10.1155/1998/961275.
To document initial investigations and treatment used in the management of children hospitalized with pertussis.
Retrospective chart review encompassing admissions from January 1, 1991 to June 1, 1995.
Six Canadian pediatric hospitals representing about 39% of the pediatric tertiary care beds in Canada.
Four hundred and forty children who met the inclusion criterion of a primary admitting diagnosis of pertussis and who did not meet the exclusion criterion of nosocomially acquired pertussis or a prior admission for pertussis during the study period.
Most patients had cultures positive for Bordetella pertussis, although the proportion of positive tests varied widely among hospitals. Erythromycin was the most commonly used medication; however, only 47% of children received the recommended dosage. Salbutamol and corticosteroids were used most often in patients with reactive airways disease. Younger children and those with reactive airways disease had longer lengths of stay in hospital.
Pertussis treatment varied widely among the six hospitals studied, and was often not consistent with current Canadian recommendations. The results will allow practitioners to place their practices in a national perspective and provide a baseline for further studies.
记录百日咳住院患儿的初始检查及治疗情况。
回顾性病历审查，涵盖1991年1月1日至1995年6月1日期间的住院病例。
六家加拿大儿科医院，约占加拿大儿科三级护理床位的39%。
440名符合百日咳主要入院诊断纳入标准，且不符合研究期间医院获得性百日咳或既往百日咳入院排除标准的儿童。
多数患者百日咳博德特氏菌培养呈阳性，不过各医院阳性检测比例差异很大。红霉素是最常用药物；然而，仅47%的儿童接受了推荐剂量。沙丁胺醇和皮质类固醇最常用于患有反应性气道疾病的患者。年龄较小的儿童及患有反应性气道疾病的儿童住院时间更长。
在所研究的六家医院中，百日咳治疗差异很大，且往往与加拿大当前的建议不一致。研究结果将使从业者能够从全国角度审视自身做法，并为进一步研究提供基线。
