Zoumboulakis D, Anagnostakis D, Albanis V, Matsaniotis N
Arch Dis Child. 1973 Jan;48(1):51-4. doi: 10.1136/adc.48.1.51.
Of 135 children with pertussis 70 were treated with steroids for 7 to 8 days and the remainder served as controls. The two groups were comparable. All children received erythromycin for 10 days. They were in the first week of the paroxysmal stage. Coughing, whooping, and vomiting episodes occurred less frequently in the steroid-treated groups, and the illness was shorter especially in babies under 1 year of age. These results indicate that steroids may have a beneficial effect on the course of pertussis if given early in the paroxysmal stage. Nevertheless, since steroids are potentially dangerous drugs we believe their use in pertussis must be limited to severe cases, particularly in infants under 6 to 9 months of age where the mortality is highest.
在135名百日咳患儿中，70名接受了7至8天的类固醇治疗，其余患儿作为对照组。两组具有可比性。所有患儿均接受了10天的红霉素治疗。他们处于阵发性阶段的第一周。在接受类固醇治疗的组中，咳嗽、痉咳和呕吐发作的频率较低，病程较短，尤其是1岁以下的婴儿。这些结果表明，如果在阵发性阶段早期给予类固醇，可能对百日咳病程有有益影响。然而，由于类固醇是有潜在危险的药物，我们认为其在百日咳中的使用必须限于重症病例，特别是在6至9个月大死亡率最高的婴儿中。
