Marinov B, Pramatarova T, Andreeva A, Larukova N, Slavov A
Akush Ginekol (Sofiia). 2011;50(6):18-20.
The physiologic mechanism that results in the occurrence of premenstrual syndrome (PMS) is not well understood.
Effective treatment in premenstrual syndrome with vitex agnus castus--femicur N in adolescent girls. [corrected].
We have investigated 45 adolescent girls 14-16 years old for a 3 years period from march 2009 to march 2011. The first group of 23 girls were prescribed Femicur N 4 mg once daily for 3 month--90 capsules per course. The second group of 22 girls were given 40 mg of the study drug (Femicur N) twice a day, from the 19th day of the first day of the cycle for 10 days 3 month as the dose is 60 capsules per course.
Our investigation showed that therapy with VAC-Femicur N in adolescents suffering from PMS was effective and the results were good. From 45 girls 20 girls (44.4%) were without any complaints and 13 girls (28.8%) had reduction of all premenstrual symptoms. In both groups premenstrual mastodynia in 13 girls (28.8%) has disappeard and with 4 girls (8.8%) complaints were redused.
导致经前综合征（PMS）发生的生理机制尚未完全明确。
探讨贞节树提取物——Femicur N对青春期女孩经前综合征的有效治疗作用。[已校正]
我们对45名年龄在14 - 16岁的青春期女孩进行了为期3年的研究，时间从2009年3月至2011年3月。第一组23名女孩，每天服用一次4毫克的Femicur N，持续3个月，每个疗程90粒胶囊。第二组22名女孩，从月经周期第一天的第19天开始，每天服用两次40毫克的研究药物（Femicur N），持续10天，共3个月，每个疗程60粒胶囊。
我们的研究表明，贞节树提取物 - Femicur N对患有经前综合征的青少年进行治疗是有效的，效果良好。45名女孩中，20名女孩（44.4%）没有任何不适，13名女孩（28.8%）所有经前症状都有所减轻。两组中，13名女孩（28.8%）的经前乳房疼痛消失，4名女孩（8.8%）的不适症状减轻。
