Penjasković Davor, Sakac Dejan, Dejanović Jovanka, Zec Radovan, Zec Petković Nada, Stojsić Milosavljević Anastazija
General Hospital Sremska Mitrovica.
Med Pregl. 2012 Jan-Feb;65(1-2):18-22.
Metabolic syndrome (MetS), which is a cluster of medical disorders, is common and it is associated with increased cardiovascular morbidity and mortality. The aim of this study was to evaluate the relationship between characteristics of metabolic syndrome and the grade of diastolic dysfunction. The study included 72 patients (29 male and 43 female), who had central obesity and at least two of the other four characteristics of metabolic syndrome according to IDF (International Diabetes Federation) criteria. The exclusion criteria were age above 65, impaired systolic function (left ventricular ejection fraction < 55%) atrial fibrillation, valvular and pericardial heart disease. Diastolic function was determined according to the criteria of the American Society of Echocardiography. There was a positive correlation between the number of characteristics of metabolic syndrome and the diastolic dysfunction grade (p < 0.0001). The positive correlation was found between the grade of diastolic dysfunction and the waist circumference (p < 0.0001), arterial hypertension (p < 0.001). pared glucose tolerance/diabetes (P = 0.0063), and hypertriglyceridemia (p = 0.0262). A low level of high-density lipoprotein did not show a statistically significant correlation. The presence of metabolic syndrome is associated with the presence of diastolic dysfunction. The grade of diastolic dysfunction is dependent on the number of coexisting characteristics of metabolic syndrome. Arterial hypertension, central obesity, hyperglycemia and hypertriglyceridemia showed a significant correlation with the degree of diastolic dysfunction.
代谢综合征（MetS）是一组医学病症，较为常见，且与心血管疾病发病率和死亡率增加相关。本研究旨在评估代谢综合征特征与舒张功能障碍分级之间的关系。该研究纳入了72例患者（29例男性和43例女性），这些患者根据国际糖尿病联盟（IDF）标准存在中心性肥胖以及代谢综合征其他四个特征中的至少两个。排除标准为年龄超过65岁、收缩功能受损（左心室射血分数<55%）、心房颤动、瓣膜性和心包性心脏病。舒张功能根据美国超声心动图学会的标准确定。代谢综合征特征数量与舒张功能障碍分级之间存在正相关（p<0.0001）。在舒张功能障碍分级与腰围（p<0.0001）、动脉高血压（p<0.001）、糖耐量异常/糖尿病（P = 0.0063）和高甘油三酯血症（p = 0.0262）之间发现了正相关。高密度脂蛋白水平低未显示出统计学上的显著相关性。代谢综合征的存在与舒张功能障碍的存在相关。舒张功能障碍分级取决于代谢综合征共存特征的数量。动脉高血压、中心性肥胖、高血糖和高甘油三酯血症与舒张功能障碍程度显示出显著相关性。
