Department of Plastic, Reconstructive, Hand and Burn Surgery, BG-Trauma Center, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Dermatol Surg. 2012 Jun;38(6):898-904. doi: 10.1111/j.1524-4725.2012.02365.x. Epub 2012 Mar 27.
There is a broad range of expensive temporary wound dressings that promise better results in wound management. The aim of this study was to compare two commonly used temporary dressings for the treatment of partial-thickness wounds in a rat model.
Forty-two partial thickness wounds were created on the back of Lewis rats and treated with the dressings; control wounds remained without treatment. Wound size was determined daily by measuring the scabbed area. Three months after the wounds were created, skin elasticity was measured and a histologic evaluation was performed.
Wound appearance in the animals in the treated groups did not differ significantly. Wound closure was slower in the control group than in the dressing groups. There was no histologic evidence of inflammation and no suggestion of epidermal changes in any group.
Using both skin dressings, we observed satisfying results without any significant differences. Because of rising health care expenses, cost should play an essential role in the clinical application of these dressings.
有许多昂贵的临时伤口敷料，它们承诺在伤口管理方面能取得更好的效果。本研究的目的是比较两种常用于治疗大鼠模型中部分厚度伤口的临时敷料。
在 Lewis 大鼠背部制造 42 个部分厚度伤口，并对其进行敷料处理；对照伤口则不做任何处理。每天通过测量结痂面积来确定伤口大小。在伤口形成 3 个月后，测量皮肤弹性并进行组织学评估。
治疗组动物的伤口外观无明显差异。对照组的伤口闭合速度比敷料组慢。任何一组均未出现炎症的组织学证据，也没有表皮变化的迹象。
使用这两种皮肤敷料，我们观察到了令人满意的结果，没有任何显著差异。由于医疗保健费用不断上涨，这些敷料的临床应用应考虑成本因素。
