Department of Food Science, University of Massachusetts, Amherst, Amherst , MA 01003, USA.
Crit Rev Food Sci Nutr. 2012;52(6):488-513. doi: 10.1080/10408398.2010.501409.
Conjugated linoleic acid (CLA) has drawn significant attention in the last two decades for its variety of biologically beneficial effects. CLA reduces body fat, cardiovascular diseases and cancer, and modulates immune and inflammatory responses as well as improves bone mass. It has been suggested that the overall effects of CLA are the results of interactions between two major isomers, cis-9,trans-11 and trans-10,cis-12. This review will primarily focus on current CLA publications involving humans, which are also summarized in the tables. Along with a number of beneficial effects of CLA, there are safety considerations for CLA supplementation in humans, which include effects on liver functions, milk fat depression, glucose metabolism, and oxidative stresses.
共轭亚油酸（CLA）在过去二十年中因其多种有益的生物学作用而受到广泛关注。CLA 可减少体脂、心血管疾病和癌症，调节免疫和炎症反应，以及改善骨量。有人认为，CLA 的总体效果是两种主要异构体 cis-9,trans-11 和 trans-10,cis-12 相互作用的结果。这篇综述将主要集中在涉及人类的 CLA 最新出版物上，这些出版物也在表格中进行了总结。除了 CLA 的许多有益作用外，CLA 补充剂对人类也有一些安全方面的考虑，包括对肝功能、乳脂减少、葡萄糖代谢和氧化应激的影响。
